The ecology of the microbiome: Networks, competition, and stability
The ecology of the microbiome: Networks, competition, and stability
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DOI：
10.1126/science.aad2602
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发表时间：
2015-11-06
期刊：
影响因子：
56.9
通讯作者：
Foster, Kevin R.
中科院分区：
文献类型：
--
作者：
Coyte, Katharine Z.;Schluter, Jonas;Foster, Kevin R.
人的肠道中有一个庞大而复杂的有益微生物群落，这些微生物在很长一段时间内保持稳定。这种稳定性被认为对健康至关重要，但人们对此知之甚少。在这里，我们发展了一套生态学理论来帮助我们理解微生物群的稳定性。尽管合作的微生物网络可能是有效的，但我们发现它们往往是不稳定的。与直觉相反的是，这一发现表明，当微生物竞争抑制合作网络并增加稳定性时，宿主可以从这种竞争中受益。更广泛地说，通过限制正反馈和削弱生态相互作用来促进稳定。我们分析了维持稳定的宿主机制--包括免疫抑制、空间结构和对社区成员的喂养--并用最近的数据支持了我们的关键预测。
The human gut harbors a large and complex community of beneficial microbes that remain stable over long periods. This stability is considered critical for good health but is poorly understood. Here we develop a body of ecological theory to help us understand microbiome stability. Although cooperating networks of microbes can be efficient, we find that they are often unstable. Counterintuitively, this finding indicates that hosts can benefit from microbial competition when this competition dampens cooperative networks and increases stability. More generally, stability is promoted by limiting positive feedbacks and weakening ecological interactions. We have analyzed host mechanisms formaintaining stability-including immune suppression, spatial structuring, and feeding of community members-and support our key predictions with recent data.