Urinary kidney injury molecule 1 (KIM-1) and interleukin 18 (IL-18) as risk markers for heart failure in older adults: the Health, Aging, and Body Composition (Health ABC) Study.
Urinary kidney injury molecule 1 (KIM-1) and interleukin 18 (IL-18) as risk markers for heart failure in older adults: the Health, Aging, and Body Composition (Health ABC) Study.
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DOI：
10.1053/j.ajkd.2014.01.432
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发表时间：
2014-07
期刊：
影响因子：
--
通讯作者：
Health ABC Study
中科院分区：
文献类型：
--
作者：
Driver TH;Katz R;Ix JH;Magnani JW;Peralta CA;Parikh CR;Fried L;Newman AB;Kritchevsky SB;Sarnak MJ;Shlipak MG;Health ABC Study
肾损害和肾功能降低是心力衰竭（HF）的潜在危险因素，但现有的研究仅限于评估蛋白尿或肾小球滤过率（eGFR）。我们评估了肾小管损伤的尿液生物标志物（白细胞介素18 [IL-18]和肾损伤分子1 [KIM-1]）与未来HF风险的关系。回顾性队列研究。健康、衰老和身体组成（Health ABC）队列中2921名无HF的参与者。尿KIM-1、IL-18和白蛋白与肌酐的比值（分别为KIM-1:Cr、IL-18:Cr和ACR）。中位随访时间为12年。基线时各标志物的中位数为：KIM-1:Cr为812 (IQR, 497-1235) pg/mg， IL-18:Cr为31 (IQR, 19-56) pg/mg， ACR为8 (IQR, 5-19) mg/g。随访期间596人发生心衰。调整多因素比例风险模型后，KIM-1:Cr的前四分位数与基线eGFR、HF危险因素和ACR相关（HR, 1.32; 95% CI, 1.02-1.70）。在危险因素和eGFR调整后的模型中，IL-18:Cr的前四分位数也与HF相关（HR, 1.35; 95% CI, 1.05-1.73），但在ACR调整后减弱（HR, 1.15; 95% CI, 0.89-1.48）。ACR的前四分位数与HF的校正相关性更强（HR, 1.96; 95% CI, 1.53-2.51）。对其他人群的普遍性是不确定的。尿中较高的KIM-1浓度与HF事件风险独立相关，尽管较高的ACR的相关性更强。
Kidney damage and reduced kidney function are potent risk factors for heart failure (HF), but existing studies are limited to assessing albuminuria or estimated glomerular filtration rate (eGFR). We evaluated the associations of urinary biomarkers of kidney tubular injury (interleukin 18 [IL-18] and kidney injury molecule 1 [KIM-1]) with future risk of HF. Retrospective cohort study. 2921 participants without HF in the Health, Aging, and Body Composition (Health ABC) cohort. Ratios of urine KIM-1, IL-18, and albumin to creatinine (KIM-1:Cr, IL-18:Cr, and ACR, respectively). Incident HF over a median follow-up of 12 years. Median values of each marker at baseline were 812 (IQR, 497–1235) pg/mg for KIM-1:Cr, 31 (IQR, 19–56) pg/mg for IL-18:Cr, and 8 (IQR, 5–19) mg/g for ACR. 596 persons developed HF during follow-up. The top quartile of KIM-1:Cr was associated with risk of incident HF after adjustment for baseline eGFR, HF risk factors, and ACR (HR, 1.32; 95% CI, 1.02–1.70) in adjusted multivariate proportional hazards models. The top quartile of IL-18:Cr was also associated with HF in a model adjusted for risk factors and eGFR (HR, 1.35; 95% CI, 1.05–1.73), but was attenuated by adjustment for ACR (HR, 1.15; 95% CI, 0.89–1.48). The top quartile of ACR had a stronger adjusted association with HF (HR, 1.96; 95% CI, 1.53–2.51). Generalizability to other populations is uncertain. Higher urine concentrations of KIM-1 were independently associated with incident HF risk, although the associations of higher ACR were of stronger magnitude.
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DOI：
10.1056/nejmoa1114248
发表时间：
2012-07-05
期刊：
The New England journal of medicine
影响因子：
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作者：
Inker LA;Schmid CH;Tighiouart H;Eckfeldt JH;Feldman HI;Greene T;Kusek JW;Manzi J;Van Lente F;Zhang YL;Coresh J;Levey AS;CKD-EPI Investigators
通讯作者：
CKD-EPI Investigators
DOI：
10.1053/j.ajkd.2011.02.391
发表时间：
2011-07
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
Blecker S;Matsushita K;Köttgen A;Loehr LR;Bertoni AG;Boulware LE;Coresh J
通讯作者：
Coresh J
影响因子：
13.6
作者：
Parikh, CR;Abraham, E;Edelstein, CL
通讯作者：
Edelstein, CL
影响因子：
13.6
作者：
Koyner, Jay L.;Garg, Amit X.;Parikh, Chirag R.
通讯作者：
Parikh, Chirag R.
DOI：
10.1053/j.ajkd.2012.05.014
发表时间：
2012-12
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
Peralta CA;Katz R;Bonventre JV;Sabbisetti V;Siscovick D;Sarnak M;Shlipak MG
通讯作者：
Shlipak MG