Expression patterns of Wnt8b and Wnt7b in the chicken embryonic brain suggest a correlation with forebrain patterning centers and morphogenesis
Expression patterns of Wnt8b and Wnt7b in the chicken embryonic brain suggest a correlation with forebrain patterning centers and morphogenesis
复制标题
DOI：
10.1016/s0306-4522(02)00171-9
复制
发表时间：
2002-01-01
期刊：
影响因子：
3.3
通讯作者：
Medina, L
中科院分区：
文献类型：
--
作者：
Garda, AL;Puelles, L;Medina, L
分析了Wnt7b和Wnt8b基因在鸡胚脑中的表达模式，特别是在前脑中。我们的研究结果表明，在早期发育阶段，cWnt8b表达的峡部组织者和其他地区假定为前脑图案中心，如禽皮质hem和丘脑内（zli）的限制。在发育后期，cWnt7b在与cWnt8b结构域相邻的区域表达，有时与cWnt8b结构域重叠，例如zli两侧的丘脑，或与皮质边缘相邻的内侧软腭。cWnt8b和cWnt7b的这种顺序表达与这些前脑区域的模式化和形态发生中的作用一致。(C)2002年IBRO。由爱思唯尔科技有限公司出版。保留所有权利。
The expression patterns of the genes Wnt7b and Wnt8b were analyzed in the brain of chick embryos, having special emphasis in the forebrain. Our results indicated that, at early developmental stages, cWnt8b is expressed in the isthmic organizer and in other areas postulated as forebrain patterning centers, such as the avian cortical hem and the zona limitans intrathalamica (zli). Later in development, cWnt7b becomes expressed in regions neighboring and sometimes overlapping the cWnt8b domains, such as the thalamus on both sides of the zli, or the medial pallium adjacent to the cortical hem. This sequential expression of cWnt8b and cWnt7b is consistent with a role in the patterning and morphogenesis of these forebrain regions. (C) 2002 IBRO. Published by Elsevier Science Ltd. All rights reserved.