Pharmacological treatment of intermittent claudication does not have a significant effect on gait impairments during claudication pain.
Pharmacological treatment of intermittent claudication does not have a significant effect on gait impairments during claudication pain.
复制标题
间歇性跛行的药物治疗对跛行疼痛期间的步态障碍没有显着效果。
DOI：
10.1123/jab.28.2.184
复制
发表时间：
2012
影响因子：
1.4
通讯作者：
Stergiou,Nicholas
中科院分区：
文献类型：
--
作者：
Yentes,JenniferM;Huisinga,JessieM;Myers,SaraA;Pipinos,IraklisI;Johanning,JasonM;Stergiou,Nicholas
外周动脉疾病（PAD）是动脉粥样硬化的一种表现，可导致间歇性跛行（IC）或体力活动期间的腿部疼痛。两种药物（西洛他唑和喷替福林）被批准用于治疗IC。我们以前的工作报告，当PAD患者无痛行走时，药物干预前后的步态生物力学没有显著差异。然而，药物可能在疼痛的步态中更有效。我们的目的是使用先进的生物力学分析来评估这些药物在疼痛行走时的有效性。对24例患者在接受西洛他唑或喷替福林治疗12周前后的初始和绝对跛行距离、关节运动学、扭矩、功率和疼痛期间的步态速度进行了测量。我们发现无论是西洛他唑或喷替福林治疗12周后，PAD患者疼痛期间的步态生物力学没有显着改善。我们的研究结果表明，药物西洛他唑和喷替福林在治疗PAD患者的步态功能障碍方面的相关性降低，即使在疼痛期间。
Peripheral arterial disease (PAD) is a manifestation of atherosclerosis resulting in intermittent claudication (IC) or leg pain during physical activity. Two drugs (cilostazol and pentoxifylline) are approved for treatment of IC. Our previous work has reported no significant differences in gait biomechanics before and after drug interventions when PAD patients walked without pain. However, it is possible that the drugs are more efficacious during gait with pain. Our aim was to use advanced biomechanical analysis to evaluate the effectiveness of these drugs while walking with pain. Initial and absolute claudication distances, joint kinematics, torques, powers, and gait velocity during the presence of pain were measured from 24 patients before and after 12 weeks of treatment with either cilostazol or pentoxifylline. We found no significant improvements after 12 weeks of treatment with either cilostazol or pentoxifylline on the gait biomechanics of PAD patients during pain. Our findings indicate that the medications cilostazol and pentoxifylline have reduced relevance in the care of gait dysfunction even during pain in patients with PAD.