Increased skin inflammation and blood vessel density in human and experimental diabetes.
Increased skin inflammation and blood vessel density in human and experimental diabetes.
复制标题
人和实验性糖尿病的皮肤炎症和血管密度增加。
DOI：
10.1177/1534734612474303
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发表时间：
2013-03
期刊：
影响因子：
--
通讯作者：
Veves A
中科院分区：
文献类型：
--
作者：
Tellechea A;Kafanas A;Leal EC;Tecilazich F;Kuchibhotla S;Auster ME;Kontoes I;Paolino J;Carvalho E;Nabzdyk LP;Veves A
糖尿病患者全身炎症与创面愈合受损有关。利用免疫组织化学技术，作者研究了人类和实验性糖尿病患者皮肤炎症和皮肤血管的变化。与非糖尿病受试者相比，糖尿病受试者每次活检的炎细胞总数和血管周围的炎细胞数量(炎症的强烈指示)高于非糖尿病受试者，无论他们发展为糖尿病足部溃疡的风险如何。与非糖尿病对照组相比，所有糖尿病动物模型的炎性细胞浸润均显著增加。糖尿病患者原有皮肤血管周围的血管和CD31阳性增殖内皮细胞的数量和密度也较高。而非糖尿病患者和糖尿病患者的皮肤血流量差异无统计学意义。糖尿病动物的皮肤血管数量也增加了，但这些差异没有炎性细胞观察到的那么明显。我们的结论是，在糖尿病受试者以及啮齿动物和兔的糖尿病模型中，皮肤炎症和皮肤血管密度增加。
Systemic inflammation is associated with impaired wound healing in diabetic patients. Using immunohistochemistry techniques, the authors investigated changes in skin inflammation and skin blood vessels in human and experimental diabetes. Comparing to the non-DM human subjects, the total number of inflammatory cells per biopsy and the number of inflammatory cells around blood vessels, a strong indication of inflammation, were higher in DM subjects irrespective of their risk for developing diabetic foot ulcer. Inflammatory cell infiltration was robustly increased in all diabetic animal models compared to their non-diabetic controls. The number and density of blood vessels and CD31 positive proliferating endothelial cells around pre-existing skin vessels was also higher in the DM patients. However, there were no differences in the skin blood flow between the non-DM and DM subjects. The number of skin blood vessels was also increased in the DM animals; however, these differences were less obvious than the ones observed for inflammatory cells. We conclude that skin inflammation and skin blood vessel density is increased in diabetic human subjects and in rodent and rabbit models of diabetes.
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影响因子：
7.7
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