Omega-3 fatty acids to augment cancer therapy
Omega-3 fatty acids to augment cancer therapy
复制标题
DOI：
10.1093/jn/132.11.3508s
复制
发表时间：
2002-11-01
影响因子：
4.2
通讯作者：
Hardman, WE
中科院分区：
文献类型：
--
作者：
Hardman, WE
动物研究结果表明，摄入 omega-3 脂肪酸可以减缓癌症异种移植物的生长，提高化疗效果并减少化疗或癌症的副作用。 omega-3 脂肪酸的多种益处的分子机制包括：1) 抑制肿瘤中环氧合酶 2 的表达，从而减少癌细胞的增殖并减少肿瘤中的血管生成； 2) 降低 AP-1 和 ras 这两个与肿瘤促进有关的癌基因的表达； 3）诱导癌细胞分化； 4)抑制核因子-kappaB激活和bcl-2表达，从而使癌细胞凋亡； 5) 减少癌症引起的恶病质。合理的假设是，经过适当的癌症治疗后，摄入 omega-3 脂肪酸可能会减缓或阻止转移性癌细胞的生长，延长癌症患者的寿命并改善他们的生活质量。
The results of animal studies have demonstrated that the consumption of omega-3 fatty acids can slow the growth of cancer xenografts, increase the efficacy of chemotherapy and reduce the side effects of the chemotherapy or of the cancer. Molecular mechanisms postulated to contribute to the multiple benefits of omega-3 fatty acids include 1) suppressing the expression of cyclooxygenase-2 in tumors, thus decreasing proliferation of cancer cells and reducing angiogenesis in the tumor; 2) decreasing the expression of AP-1 and ras, two oncogenes implicated in tumor promotion; 3) inducing differentiation of cancer cells; 4) suppressing nuclear factor-kappaB activation and bcl-2 expression, thus allowing apoptosis of cancer cells; and 5) reducing cancer-induced cachexia. It seems reasonable to assume that after appropriate cancer therapy, consumption of omega-3 fatty acids might slow or stop the growth of metastatic cancer cells, increase longevity of cancer patients and improve their quality of life.