Brown Adipose Tissue Development and Metabolism.
Brown Adipose Tissue Development and Metabolism.
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DOI：
10.1007/164_2018_168
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发表时间：
2019
影响因子：
--
通讯作者：
Guertin DA
中科院分区：
文献类型：
--
作者：
Jung SM;Sanchez-Gurmaches J;Guertin DA
众所周知，棕色脂肪组织是一种在小型啮齿动物和人类婴儿中特别重要的体温调节器官，但直到最近，人们才广泛认识到它的存在及其对成人代谢健康的意义。活性棕色脂肪消耗大量能量的能力引起了人们对刺激生热疗法治疗与肥胖和2型糖尿病相关的代谢性疾病的兴趣。与此同时，旨在了解啮齿动物和人类棕色脂肪发育的生物学、其显著的代谢特性以及白色脂肪褐化现象的研究激增。在白色脂肪褐化现象中，白色脂肪细胞可以转化为具有相似生热特性的棕色样脂肪细胞。在这里，我们回顾了目前对参与形成生热脂肪细胞的发育和代谢途径的了解，并强调了棕色脂肪的许多未知功能，使其研究成为未来丰富和令人兴奋的研究领域。
Brown adipose tissue is well known to be a thermoregulatory organ particularly important in small rodents and human infants, but it was only recently that its existence and significance to metabolic fitness in adult humans have been widely realized. The ability of active brown fat to expend high amounts of energy has raised interest in stimulating thermogenesis therapeutically to treat metabolic diseases related to obesity and type 2 diabetes. In parallel, there has been a surge of research aimed at understanding the biology of rodent and human brown fat development, its remarkable metabolic properties, and the phenomenon of white fat browning, in which white adipocytes can be converted into brown like adipocytes with similar thermogenic properties. Here, we review the current understanding of the developmental and metabolic pathways involved in forming thermogenic adipocytes, and highlight some of the many unknown functions of brown fat that make its study a rich and exciting area for future research.