Circular RNAs and competing endogenous RNA (ceRNA) networks.

Circular RNAs and competing endogenous RNA (ceRNA) networks.
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DOI:
10.21037/tcr.2018.05.12
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发表时间:
2018-06
影响因子:
0.9
通讯作者:
Park KS
Park KS
中科院分区:
医学4区
文献类型:
--
作者:
Mitra A;Pfeifer K;Park KS

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近年来,生物信息学方法的进步已经允许对各种细胞类型的环状rna (circRNAs)进行系统表征。细胞类型特异性的证明、调控表达和物种间的保守性都表明circRNAs具有重要的功能。特别是,研究人员已经开始关注circRNAs作为竞争性内源性RNA (ceRNA)调控网络的一部分运作的可能性,该网络被认为在正常发育和癌症等病理条件中发挥关键作用。
In recent years, advances in bioinformatics approaches have allowed a systematic characterization of circular RNAs (circRNAs) across a variety of cell types. Demonstration of cell type specificity, regulated expression, and conservation between species all suggest that circRNAs have functional importance. Especially, investigators have begun focusing on the possibility that circRNAs operate as part of competing endogenous RNA (ceRNA) regulatory networks that are proposed to play critical roles in normal development and in pathologic conditions like cancer.
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