Healthy dietary patterns and risk of breast cancer by molecular subtype.
Healthy dietary patterns and risk of breast cancer by molecular subtype.
复制标题
通过分子亚型的健康饮食模式和乳腺癌的风险。
DOI：
10.1007/s10549-016-3706-2
复制
发表时间：
2016-02
影响因子：
3.8
通讯作者：
Eliassen AH
中科院分区：
文献类型：
--
作者：
Hirko KA;Willett WC;Hankinson SE;Rosner BA;Beck AH;Tamimi RM;Eliassen AH
我们在前瞻性护士健康研究（NHS）队列中的100，643名女性中按分子亚型检查了饮食质量指数与乳腺癌风险之间的关系，随访时间为1984年至2006年。根据每2-4年收集的半定量食物频率问卷，计算替代健康饮食指数（AHEI）、替代地中海饮食（aMED）和阻止高血压饮食方法（DASH）饮食模式的饮食质量评分。根据免疫染色肿瘤微阵列的雌激素受体（ER）、孕激素受体（PR）、人表皮生长因子2（HER 2）、细胞角蛋白5/6（CK 5/6）和表皮生长因子受体（EGFR）状态结合组织学分级来定义乳腺癌分子亚型。考克斯比例风险模型，调整年龄和乳腺癌的危险因素，用于估计风险比（HR）和95%置信区间（CI）。竞争风险分析用于评估亚型的异质性。我们没有观察到AHEI或aMED饮食模式与分子亚型乳腺癌风险之间的任何显着关联。然而，在DASH饮食模式的第5个五分位数与第1个五分位数的女性中观察到HER 2型乳腺癌的风险显著降低（n=134例，Q5与Q1 HR（95%CI）=0.44（0.25-0.77）），并且五分位数之间的反向趋势是显著的（p趋势=0.02）。我们没有观察到AHEI（phet =0.25），aMED（phet =0.71）和DASH（phet =0.12）饮食模式与乳腺癌亚型之间的相关性有任何异质性。坚持AHEI、aMED和DASH饮食模式与乳腺癌分子亚型没有强相关性。
We examined associations between dietary quality indices and breast cancer risk by molecular subtype among 100,643 women in the prospective Nurses' Health Study (NHS) cohort, followed from 1984 to 2006. Dietary quality scores for the Alternative Healthy Eating Index (AHEI), alternate Mediterranean diet (aMED), and Dietary Approaches to Stop Hypertension (DASH) dietary patterns were calculated from semi-quantitative food frequency questionnaires collected every 2-4 years. Breast cancer molecular subtypes were defined according to estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor 2 (HER2), cytokeratin 5/6 (CK5/6) and epidermal growth factor receptor (EGFR) status from immunostained tumor microarrays in combination with histologic grade. Cox proportional hazards models, adjusted for age and breast cancer risk factors, were used to estimate hazard ratios (HR) and 95% confidence intervals (CI). Competing risk analyses were used to assess heterogeneity by subtype. We did not observe any significant associations between the AHEI or aMED dietary patterns and risk of breast cancer by molecular subtype. However, a significant reduced risk of HER2-type breast cancer was observed among women in 5th vs. 1st quintile of the DASH dietary pattern (n=134 cases, Q5 vs. Q1 HR (95%CI) =0.44(0.25-0.77)), and the inverse trend across quintiles was significant (p-trend=0.02). We did not observe any heterogeneity in associations between AHEI (phet =0.25), aMED (phet =0.71) and DASH (phet =0.12) dietary patterns and breast cancer by subtype. Adherence to the AHEI, aMED, and DASH dietary patterns was not strongly associated with breast cancer molecular subtypes.