Dual-Peptide-Functionalized Albumin-Based Nanoparticles with pH-Dependent Self-Assembly Behavior for Drug Delivery
Dual-Peptide-Functionalized Albumin-Based Nanoparticles with pH-Dependent Self-Assembly Behavior for Drug Delivery
复制标题
DOI：
10.1021/acsami.5b03866
复制
发表时间：
2015-07-22
影响因子：
9.5
通讯作者：
Cheng, Si-Xue
中科院分区：
文献类型：
--
作者：
Chen, Bin;He, Xiao-Yan;Cheng, Si-Xue
药物输送已成为提高化疗效率的重要策略。在这里，我们开发了一种多功能的基于白蛋白的纳米药物传递系统，具有肿瘤靶向性、细胞穿透性和内溶体pH响应特性。以cRGD为肿瘤靶向配体，通过细胞穿透肽Kala与cRGD-BSA之间的静电相互作用，制备了cRGD-BSA/Kala/DOX纳米粒子。在胞内体/溶酶体的酸性条件下，cRGD-BSA和KALA的电荷变化导致纳米粒解体，加速细胞内药物释放。CRGD-BSA/KALA/DOX纳米粒对α(V)-β(3)-整合素过表达的肿瘤细胞的生长具有增强的抑制作用，表明其在癌症治疗中具有良好的应用前景。
Drug delivery has become an important strategy for improving the chemotherapy efficiency. Here we developed a multifunctionalized nanosized albumin-based drug-delivery system with tumor-targeting, cell-penetrating, and endolysosomal pH-responsive properties. cRGD-BSA/KALA/DOX nanoparticles were fabricated by self-assembly through electrostatic interaction between cell-penetrating peptide KALA and cRGD-BSA, with cRGD as a tumor-targeting ligand. Under endosomal/lysosomal acidic conditions, the changes in the electric charges of cRGD-BSA and KALA led to the disassembly of the nanoparticles to accelerate intracellular drug release. cRGD-BSA/KALA/DOX nanoparticles showed an enhanced inhibitory effect in the growth of alpha(v)beta(3)-integrin-overexpressed tumor cells, indicating promising application in cancer treatments.