THE EFFECT OF EVENING BRIGHT LIGHT IN DELAYING THE CIRCADIAN-RHYTHMS AND LENGTHENING THE SLEEP OF EARLY-MORNING AWAKENING INSOMNIACS
THE EFFECT OF EVENING BRIGHT LIGHT IN DELAYING THE CIRCADIAN-RHYTHMS AND LENGTHENING THE SLEEP OF EARLY-MORNING AWAKENING INSOMNIACS
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DOI：
10.1093/sleep/16.5.436
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发表时间：
1993-08-01
期刊：
影响因子：
5.6
通讯作者：
WRIGHT, H
中科院分区：
文献类型：
--
作者：
LACK, L;WRIGHT, H
过去的研究预测，早醒失眠与先进或早期的昼夜节律有关。由于晚上的强光刺激可以延迟昼夜节律的相位，我们测试了9名（4名女性，5名男性）清晨醒来的失眠症患者的效果。他们的睡眠进行了评估与腕关节活动，他们的温度和褪黑激素昼夜节律进行了测量，在恒定的常规程序。在最初的评估中，这些失眠症患者的温度节律相位位置确实比正常人早。然后，受试者在连续两个晚上的2000至2400小时暴露于强光刺激（2，500勒克斯）。在夜间强光处理后，温度节律相位标记物延迟2-4小时，褪黑激素相位标记物延迟1-2小时。睡眠开始时间没有改变，但平均最终醒来时间从0459小时延迟到0611小时，导致总睡眠时间平均增加> 1小时。这项初步研究表明，晚上明亮的光刺激可能是一种有效的非药物治疗清晨觉醒失眠。
Past studies have predicted that early morning awakening insomnia is associated with advanced or early circadian rhythms. Because bright light stimulation in the evening can delay the phase of circadian rhythms, we tested its effects on nine (4 females, 5 males) early morning awakening insomniacs. Their sleep was evaluated with wrist actigraphy and their temperature and melatonin circadian rhythms were measured in constant routine procedures. In the initial evaluation, the temperature rhythm phase positions of these insomniacs did appear to be earlier than normal. The subjects were then exposed to bright light stimulation (2,500 lux) from 2000 to 2400 hours on two consecutive evenings. Following the evening bright light treatment, temperature rhythm phase markers were delayed 2-4 hours and melatonin phase markers were delayed 1-2 hours. Sleep onset times were not changed but the mean final wake-up time was delayed from 0459 hours to 0611 hours, resulting in a mean increase of total sleep time of > 1 hour. This pilot study suggests that evening bright light stimulation may be an effective nondrug treatment for early morning awakening insomnia.