2001 Warkany lecture: to die or not to die, the role of apoptosis in normal and abnormal mammalian development.
2001 Warkany lecture: to die or not to die, the role of apoptosis in normal and abnormal mammalian development.
复制标题
2001年Warkany演讲：死还是不死，细胞凋亡在正常和异常哺乳动物发育中的作用。
DOI：
10.1002/tera.10049
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Mirkes,PhilipE
中科院分区：
文献类型：
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作者：
Mirkes,PhilipE
细胞死亡是许多哺乳动物组织/器官发育的共同和可重复的特征。两个众所周知的程序性细胞死亡（PCD）的例子是指形成过程中与神经折叠融合和指间充质细胞去除相关的细胞死亡。与正常发育一样，畸形发育也与暴露于多种致畸原后发育异常的组织/器官中细胞死亡增加有关。至少在某些情况下，致畸原诱导正常PCD区域的细胞死亡，这表明程序性细胞死亡和致畸原诱导的细胞死亡之间存在联系。尽管研究人员很早就认识到细胞死亡是正常和异常发育的一个组成部分，但对细胞死亡的机制知之甚少。1972年，Kerr等人（' 72）结论性地表明，在各种情况下诱导的细胞死亡遵循一种可重复的模式，他们称之为凋亡。下一个突破出现在20世纪80年代，当时霍维茨和他的同事们发现了控制蛔虫PCD的特定细胞死亡基因（ced），
Cell death is a common and reproducible feature of the development of many mammalian tissues/organs. Two well-known examples of programmed cell death (PCD) are the cell deaths associated with fusion of the neural folds and removal of interdigital mesenchymal cells during digit formation. Like normal development, abnormal development is also associated with increased cell death in tissues/organs that develop abnormally after exposure to a wide variety of teratogens. At least in some instances, teratogens induce cell death in areas of normal PCD, suggesting that there is a link between programmed and teratogen-induced cell death. Although researchers recognized early on that cell death is an integral part of both normal and abnormal development, little was known about the mechanisms of cell death. In 1972, Kerr et al.(’72) showed conclusively that cell deaths, induced in a variety of contexts, followed a reproducible pattern, which they termed apoptosis. The next breakthrough came in the 1980s when Horvitz and his colleagues identified specific cell death genes (ced) that controlled PCD in the roundworm,