Significance of RBP4 in patients with gestational diabetes mellitus: a case-control study of Han Chinese women
Significance of RBP4 in patients with gestational diabetes mellitus: a case-control study of Han Chinese women
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RBP4在妊娠期糖尿病患者中的意义：中国汉族女性的病例对照研究
DOI：
10.3109/09513590.2013.871515
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发表时间：
2014-02-01
影响因子：
2
通讯作者：
Chen Danqing
中科院分区：
文献类型：
--
作者：
Liang Zhaoxia;Du Mengkai;Chen Danqing
视黄醇结合蛋白4 （RBP4）在胰岛素抵抗中的作用最近被发现。本研究通过对妊娠期糖尿病（GDM）妇女的病例对照研究，探讨了RBP4水平与脂质和糖代谢的相关性。在2008年5月至2010年5月期间，招募了70名孕妇（妊娠24-28周），其中包括35名患有GDM的妇女和35名健康对照。在口服糖耐量试验（OGTT）前后采集血样，检测血清RBP4、胰岛素、糖化血红蛋白、甘油三酯（TG）和总胆固醇（TC）水平；计算胰岛素抵抗指数（HOMA-IR）。GDM组血清RBP4水平显著高于对照组（22.9±3.09µg/ml vs 17.9±3.91µg/ml; p < 0.01）。GDM组及对照组胰岛素、TC、TG水平均显著高于对照组（p < 0.05）。GDM组血清RBP4水平与给糖后1 h、2 h HOMA-IR、TG、血糖水平相关（r分别为0.49、0.49、0.52、0.52,p < 0.01）。结论：GDM患者血清RBP4水平高于对照组。此外，RBP4与胰岛素抵抗、糖脂代谢异常相关。
Abstract The role of retinol binding protein 4 (RBP4) in insulin resistance was recently identified. Our study investigated the correlation between RBP4 levels with lipid and glucose metabolism in a case-control study of women with gestational diabetes mellitus (GDM). Between May 2008 and May 2010, 70 pregnant women (24–28 weeks gestation) were recruited, including 35 women with GDM and 35 healthy controls. Blood samples were collected prior to and after oral glucose tolerance tests (OGTT) to detect serum RBP4, insulin, glycated hemoglobin, triglyceride (TG) and total cholesterol (TC) levels; the insulin resistance index (HOMA-IR) was calculated. Serum RBP4 levels in the GDM group were significantly higher than the control group (22.9 ± 3.09 µg/ml versus 17.9 ± 3.91 µg/ml; p < 0.01). Insulin, TC and TG levels in the GDM group and the control group were all significantly higher than the control group (p < 0.05). Serum RBP4 levels in the GDM group were correlated with HOMA-IR, TG and blood glucose levels at 1 h and 2 h after glucose was administered (r = 0.49, 0.49, 0.52,0.52, respectively; p < 0.01). In conclusion, serum RBP4 levels are elevated in GDM cases than controls. In addition, RBP4 correlates with abnormalities of insulin resistance, glucose and lipid metabolism.