Neuroprotective effects of chronic lithium on focal cerebral ischemia in rats
Neuroprotective effects of chronic lithium on focal cerebral ischemia in rats
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DOI：
10.1097/00001756-199806220-00031
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发表时间：
1998-06-22
期刊：
影响因子：
1.7
通讯作者：
Chuang, DM
中科院分区：
文献类型：
--
作者：
Nonaka, S;Chuang, DM
我们最近发现，长期但非急性的锂治疗有力地保护培养的中枢神经系统神经元免受NMDA受体介导的兴奋性毒性。鉴于NMDA受体过度兴奋与缺血性脑损伤密切相关，我们观察了慢性锂盐治疗对大鼠左侧大脑中动脉闭塞所致神经功能障碍和脑梗塞的影响。皮下注射氯化锂16天显著改善神经功能缺陷，包括动脉闭塞后24小时测量的姿势异常和偏瘫。重要的是，锂盐预处理后，缺血性脑梗塞的面积缩小了56%。这些结果增加了锂可能有助于减少局灶性脑缺血引起的脑损伤和神经异常的可能性。(C)1998年Rapid Science Ltd.
WE have recently shown that long-term, but not acute, treatment with lithium robustly protects cultured CNS neurons against excitotoxicity mediated by NMDA receptors. Since NMDA receptor over-excitation has been strongly implicated in the ischemic brain injury, we examined the effects of chronic lithium treatment on neurological deficit and brain infarct induced by occlusion of the left middle cerebral artery in rats. Subcutaneous injection of LiCl for 16 days significantly improved neurological deficits, including abnormal posture and hemiplegia, measured 24h after artery occlusion. Importantly, the size of ischemic infarct was reduced by 56% after lithium pretreatment. These results raise the possibility that lithium may be useful for reducing focal ischemia-induced brain damage and neurological abnormalities. (C) 1998 Rapid Science Ltd.