Association of Serum Lipids with Macular Thickness and Volume in Type 2 Diabetes without Diabetic Macular Edema.
Association of Serum Lipids with Macular Thickness and Volume in Type 2 Diabetes without Diabetic Macular Edema.
复制标题
血清脂质与无糖尿病黄斑水肿的 2 型糖尿病黄斑厚度和体积的关系。
DOI：
10.1167/iovs.13-13035
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Ozawa Y
中科院分区：
文献类型：
--
作者：
Sasaki M;Kawashima M;Kawasaki R;Uchida A;Koto T;Shinoda H;Tsubota K;Jie Jin Wang;Ozawa Y
目的：评估光学相干断层扫描(OCT)所示的黄斑厚度和体积与糖尿病视网膜病变(DR)或黄斑水肿(DME)的已知危险因素之间的关系。方法：74例无DME且无或仅有少量DR的2型糖尿病患者(n=67无DR；n=7伴最小DR；平均年龄59.5岁)。用光谱域OCT测量中心亚区黄斑厚度和中心亚区黄斑体积，中心亚区黄斑厚度为500-μm半径。结果：平均CSMT值为273.7±17.8mm3，平均CSMV值为0.215±0.015μm。在调整了年龄、性别、糖尿病病程、糖化血红蛋白、尿蛋白等因素后，低密度脂蛋白胆固醇水平与CSMT和CSMV呈正相关，低密度脂蛋白每升高1μ/Mol，CSMT平均增加6.5 2 mM(95%可信区间为1.96~11.08；P=0.006)，CSMV平均增加0.0047 mm3(95%CI为0.001~0.0085；P=0.015)。有必要进行前瞻性的纵向研究，以评估同时具有较高的低密度脂蛋白水平和较高的CSMT或CSMV是否为DME后续发展的风险指标。
Purpose.: To assess the relationship between macular thickness and volume as characterized by optical coherence tomography (OCT) and known risk factors for diabetic retinopathy (DR) or macular edema (DME) in type 2 diabetic patients with no DME.Methods.: Seventy-four patients with type 2 diabetes without DME and no or only minimal DR (n= 67 with no DR; n= 7 with minimal DR; mean age, 59.5 years) were recruited at a tertiary eye hospital. Central subfield macular thickness (CSMT; circle of 500-μm radius) and central subfield macular volume (CSMV) were measured using spectral-domain OCT. Associations between OCT parameters and known risk factors for DR were examined using multiple linear regression models.Results.: The mean CSMT and CSMV values were 273.7±17.8 μm and 0.215±0.015 mm 3, respectively. After adjusting for age, sex, duration of diabetes, hemoglobin A1c, and urine protein, low-density lipoprotein (LDL) cholesterol was positively associated with CSMT and CSMV; each 1 mmol/L increase in LDL was associated with a mean increase in CSMT of 6.52 μm (95% confidence interval [CI], 1.96–11.08; P= 0.006) and a mean increase in CSMV of 0.0047 mm 3 (95% CI, 0.001–0.0085; P= 0.015).Conclusions.: A higher LDL cholesterol level was associated with increased CSMT and CSMV in diabetic patients without DME. Prospective longitudinal studies are warranted to assess whether having both elevated levels of LDL and higher CSMT or CSMV is a risk indicator for subsequent development of DME.