Anorectic effect of leptin is mediated by hypothalamic corticotropin-releasing hormone, but not by urocortin, in rats
Anorectic effect of leptin is mediated by hypothalamic corticotropin-releasing hormone, but not by urocortin, in rats
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在大鼠中，瘦素的厌食作用是由下丘脑促肾上腺皮质激素释放激素介导的，但不是由尿皮质素介导的
DOI：
10.1016/s0304-3940(01)01959-0
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发表时间：
2001
影响因子：
2.5
通讯作者：
M. Saito
中科院分区：
文献类型：
--
作者：
S. Okamoto;K. Kimura;M. Saito
瘦素是一种关键的传入信号，通过作用于下丘脑中的特定受体，减少食物摄入量，增加能量消耗。促肾上腺皮质激素释放激素(CRH)及其同源多肽urocortin在脑内给药时也被认为有很强的厌食作用。为了确定这两种多肽可能参与瘦素诱导的厌食症，在本研究中，测量了CRH和urocortin抗体预处理的大鼠的摄食量。在未经抗体处理的对照组大鼠，侧脑室注射瘦素(0.1-1μg/只)可抑制大鼠夜间摄食。在脑室注射抗CRH抗体的大鼠中，瘦素的厌食作用显著减弱，但不能用抗尿皮质素抗体处理。这些结果表明，瘦素的厌食作用是由CRH介导的，而不是由Urocortin在下丘脑介导的。
Leptin is a key afferent signal that decreases food intake and increases energy expenditure by acting on the specific receptors in the hypothalamus. Corticotropin-releasing hormone (CRH) and its homologous peptide, urocortin, are also known to have a potent anorectic effect when given intracranially. To determine possible involvement of these two peptides in the leptin-induced anorexia, in the present study, food intake was measured in rats pretreated with antibodies against CRH and urocortin. In the control rats without antibody pretreatment, intracerebroventricular (icv) injection of leptin (0.1–1 μg/rat) suppressed nocturnal food intake. The anorectic effect of leptin was substantially attenuated in rats pretreated with icv injection of an anti-CRH antibody, but not with an anti-urocortin antibody. These results suggest that the anorectic effect of leptin is mediated by CRH, but not by urocortin, in the hypothalamus.
影响因子：
15.9
作者：
Schwartz, MW;Seeley, RJ;Baskin, DG
通讯作者：
Baskin, DG
DOI：
10.1073/pnas.94.13.7001
发表时间：
1997-06-24
影响因子：
11.1
作者：
Fei, H;Okano, HJ;Friedman, JM
通讯作者：
Friedman, JM