Water extract of the root of Lindera strychnifolia slows down the progression of diabetic nephropathy in db/db mice
Water extract of the root of Lindera strychnifolia slows down the progression of diabetic nephropathy in db/db mice
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DOI：
10.1016/j.lfs.2005.04.018
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发表时间：
2005-08-05
期刊：
影响因子：
6.1
通讯作者：
Fujiwara, H
中科院分区：
文献类型：
--
作者：
Ohno, T;Takemura, G;Fujiwara, H
我们研究了林德拉根（Linderac radix，简称LR）对糖尿病肾病进展的可能预防作用。以遗传糖尿病模型C57BL/KsJ-db/db （db/db）小鼠为实验对象，以730 mg/kg/d的剂量口服林芝水提物（LR提取物）12周。枸梨提取物对糖代谢和收缩压无影响。然而，通过肌酐清除率（Cer）和血清肌酐来评估，其肾功能优于对照组；对照组Ccr和血清肌酐逐渐恶化（分别为0.13 +/- 0.01（1天）和0.69 +/- 0.04 (mg/dl)），而治疗组无明显变化（分别为0.24 +/- 0.03（1天）和0.53 +/- 0.04 (mg/dl), p < 0.05）。与对照组相比，LR提取物处理组肾小球面积和细胞数量更大，肾小球硬化指数更小，肾小球纤维化更少，肾小球细胞凋亡率降低。此外，LR提取物处理组肾脏tgf - β(1)表达降低。这些发现表明，LR治疗可能是一种新的治疗糖尿病肾病的方法。(c) 2005年Elsevier Inc.出版
We examined a possible preventive effect of Linderac radix (LR), the root of Lindera strychnifolia, on the progression of diabetic nephropathy. Water extract of Linderae radix (LR extract) was orally administered to the C57BL/KsJ-db/db (db/db) mice, a model of genetic diabetes, at a dose of 730 mg/kg/day for 12 week. The LR extract treatment did not affect glucose metabolism and systolic pressure. However, it resulted in a better renal function as evaluated by creatinine clearance (Cer) and serum creatinine than the control; Ccr and serum creatinine were progressively worsened in controls (0.13 +/- 0.01 (Yday) and 0.69 +/- 0.04 (mg/dl), respectively) whereas unchanged in the treated group (0.24 +/- 0.03 (1/day), p < 0.05 and 0.53 +/- 0.04 (mg/dl), p < 0.05, respectively). Kidneys of the LR extract-treated group showed glomeruli with greater area and cell population, smaller glomerular sclerotic index, and less fibrosis in glomeruli, where apoptotic rate of glomerular cells were decreased compared with the control kidneys. Furthermore, renal TGF-beta(1) expression was decreased in the LR extract-treated group. These findings suggest that the LR therapy can be a novel therapeutic approach against diabetic nephropathy. (c) 2005 Published by Elsevier Inc.