Is P50 suppression a measure of sensory gating in schizophrenia?
Is P50 suppression a measure of sensory gating in schizophrenia?
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DOI：
10.1016/s0006-3223(98)00115-2
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发表时间：
1998-06-15
影响因子：
10.6
通讯作者：
Potkin, SG
中科院分区：
文献类型：
--
作者：
Jin, Y;Bunney, WE;Potkin, SG
背景：异常P50反应被认为反映了精神分裂症的感觉门控缺陷。尽管有大量的文献涉及传感器，过滤或门控缺陷的精神分裂症，没有证据已经提供了测试的关系P50现象与患者的经验知觉异常。方法：十六个无毒的DSM-IV诊断的精神分裂症患者谁报告中度至重度知觉异常的听觉或视觉方式进行了检查相比，16精神分裂症患者谁没有结果：知觉异常患者的P50波型与正常人无显著差异，知觉异常患者的P50波型与正常人无显著差异。结论：这些矛盾的发现不支持P50与感觉门控行为测量之间的假设关系，提示需要更多的研究来进一步探索P50的临床意义。(C)1998年生物精神病学学会。
Background: Abnormal P50 response has been hypothesized to reflect the sensory gating deficit in schizophrenia. Despite the extensive literature concerning the sensor), filtering or gating deficit in schizophrenia, no evidence has been provided to test the relationship of the P50 phenomenon with patients' experiences of perceptual anomalies.Methods: Sixteen drug-free DSM-IV diagnosed schizophrenic patients who reported moderate to severe perceptual anomalies in the auditory or visual modality were examined as compared to 16 schizophrenic patients who did not report perceptual anomalies, and 16 normal subjects, Both control groups were age- and gender-matched with the study group.Results: Patients reporting perceptual anomalies exhibited P50 patterns that did not differ from normal subjects. III contrast, patients who did not report perceptual anomalies showed the abnormal P50 ratios previous found to be associated with schizophrenia.Conclusions: these paradoxical findings do riot support the hypothetical relationship between the P50 and behavioral measures of sensory gating, suggesting that additional studies are needed to further explore the clinical con-elates of the P50. (C) 1998 Society of Biological Psychiatry.