Thermal effects of focused ultrasound on the brain: Determination with MR imaging
Thermal effects of focused ultrasound on the brain: Determination with MR imaging
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DOI：
10.1148/radiology.204.1.9205255
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发表时间：
1997-07-01
期刊：
影响因子：
19.7
通讯作者：
Jolesz, FA
中科院分区：
文献类型：
--
作者：
Hynynen, K;Vykhodtseva, NI;Jolesz, FA
目得：为了确定使用温度敏感的磁共振（MR）成像的可行性，用于检测局部温度升高的低功率超声波束在brain.MATERIALS和METHODS的焦点：在28只兔子的大脑声功率水平为3.5-17.5 W。在每只家兔中，以不同的声功率水平对四到五个不同的位置进行超声处理。在超声处理后2小时、48小时、10天和23天获得MR图像，这取决于动物何时被处死。组织学评价整个brain.Results：43（93%）的最低功率（3.5-W）sonications是可见的温度敏感的MR图像，并没有导致任何短期或长期的组织学或MR成像证据的组织损伤。A contrast-to-noise ratio of approximately 6 and a temperature elevation of 7 degrees-8 degrees C were observed.CONCLUSION：温度升高引起的聚焦超声暴露，不造成损害，在体内兔脑可以检测到在温度敏感的MR成像。
PURPOSE: To determine the feasibility of the use of temperature-sensitive magnetic resonance (MR) imaging for the detection of local temperature elevations at the focus of a low-power ultrasound beam in the brain.MATERIALS AND METHODS: The brains in 28 rabbits were sonicated at acoustic power levels of 3.5-17.5 W. Four to five different locations were sonicated at different acoustic power levels in each rabbit. MR images were obtained 2 hours, 48 hours, 10 days, and 23 days after the sonications, depending on when the animals were sacrificed. Histologic evaluation of whole brain was performed.RESULTS: Forty of 43 (93%) of the lowest-power (3.5-W) sonications were visible on temperature-sensitive MR images and did not result in any short- or long-term histologic or MR imaging evidence of tissue damage. A contrast-to-noise ratio of approximately 6 and a temperature elevation of 7 degrees-8 degrees C were observed.CONCLUSION: Temperature elevations induced by means of focused ultrasound exposures that do not cause damage in the in vivo rabbit brain can be detected at temperature-sensitive MR imaging.