A DROSOPHILA GENE ENCODING A PROTEIN RESEMBLING THE HUMAN BETA-AMYLOID PROTEIN-PRECURSOR
A DROSOPHILA GENE ENCODING A PROTEIN RESEMBLING THE HUMAN BETA-AMYLOID PROTEIN-PRECURSOR
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DOI：
10.1073/pnas.86.7.2478
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发表时间：
1989-04-01
影响因子：
11.1
通讯作者：
WHITE, K
中科院分区：
文献类型：
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作者：
ROSEN, DR;MARTINMORRIS, L;WHITE, K
我们已经分离了类似于人β-内酰胺酶基因的果蝇基因的基因组和cDNA克隆。淀粉样前体蛋白（APP）。该基因产生神经系统富集的6.5-腺苷酸酶转录物。从6.5-腺苷酸酶转录物衍生的cDNA的测序预测了886个氨基酸的多肽。该多肽含有推定的跨膜结构域，并表现出与人β-内酰胺酶的细胞质和细胞外区域的强序列相似性。淀粉样前体蛋白有一个很大的可能性，这个果蝇基因对应于果蝇的基本基因座vnd，胚胎神经系统发育所需的基因。
We have isolated genomic and cDNA clones for a Drosophila gene resembling the human .beta.-amyloid precursor protein (APP). This gene produces a nervous system-enriched 6.5-kilobase transcript. Sequencing of cDNAs derived from the 6.5-kilobase transcript predicts an 886-amino acid polypeptide. This polypeptide contains a putative transmembrane domain and exhibits strong sequence similarity to cytoplasmic and extracellular regions of the human .beta.-amyloid precursor protein. There is a high probability that this Drosophila gene corresponds to the essential Drosophila locus vnd, a gene required for embryonic nervous system development.