Optical coherence tomography: A pilot study of a new imaging technique for noninvasive examination of cervical tissue
Optical coherence tomography: A pilot study of a new imaging technique for noninvasive examination of cervical tissue
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DOI：
10.1016/j.ajog.2004.11.054
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发表时间：
2005-07-01
影响因子：
9.8
通讯作者：
Richards-Kortum, R
中科院分区：
文献类型：
--
作者：
Zuluaga, AF;Follen, M;Richards-Kortum, R
目的：光学相干层析成像（OCT）是一种新型的无创成像技术，它能以10 ~ 20 μ m的分辨率对亚表面组织结构进行成像。本研究的目的是确定OCT成像系统是否可以在临床上体内使用，以成像和区分正常和异常宫颈组织的特征。研究设计：宫颈OCT图像和活检标本从同意的志愿者中获得。定量分析图像的上皮反向散射光强度和上皮深度上信号衰减率（斜率）。根据绝经状态对患者进行分层，并比较正常和异常宫颈样本的参数，如常规组织病理学技术所诊断的。
Objective: Optical coherence tomography (OCT) is a novel noninvasive technique that can map subsurface tissue structure with a resolution of 10 to 20 mu m. The objective of this study was to determine whether an OCT imaging system could be used clinically in vivo to image and distinguish features of normal and abnormal cervical tissue.Study design: Cervical OCT images and biopsy specimens were obtained from consenting volunteers. Images were analyzed quantitatively for intensity of backscattered light from the epithelia and for rates of signal decay of signal over the depth of epithelia (slope). Patients were stratified by menopausal status, and parameters were compared in normal and abnormal cervical samples, as diagnosed by routine histopathologic techniques.Results: Average epithelial intensities were significantly stronger in the abnormal tissue than in the normal tissue of premenopausal women (P