In Vivo assessment of myocardial stiffness with acoustic radiation force impulse imaging
In Vivo assessment of myocardial stiffness with acoustic radiation force impulse imaging
复制标题
DOI：
10.1016/j.ultrasmedbio.2007.05.009
复制
发表时间：
2007-11-01
影响因子：
2.9
通讯作者：
Trahey, Gregg E.
中科院分区：
文献类型：
--
作者：
Hsu, Stephen J.;Bouchard, Richard R.;Trahey, Gregg E.
声辐射力脉冲（ARFI）成像已被证明能够可视化软组织内局部刚度的变化。ARFI射束排序和并行成像的最新进展缩短了采集时间，并减少了传感器发热，使ARFI采集可以在商用诊断扫描仪上以高帧速率执行。在体内ARFI图像采集与线性阵列放置在暴露的犬心脏。还记录了心电图（ECG）。当与ECG共配准时，心脏的ARFI位移图像反映了心动周期期间预期的心肌硬度变化。在左心室游离壁的心外膜表面进行射频消融，形成一个小的损伤，在心跳期间硬度不变，但继续与心脏的其余部分一起移动。ARFI图像显示，在消融部位的半球形，僵硬的区域，通过心动周期的位移幅度和时间变化小于周围未经处理的心肌。采集辐射力脉冲幅度设置为零的序列，以测量ARFI图像内的潜在心脏运动伪影。结果表明，实时心脏ARFI成像的承诺。（电子邮件：stephen.j. duke.edu）（c）2007年世界医学和生物学超声联合会。
Acoustic radiation force impulse (ARFI) imaging has been demonstrated to be capable of visualizing variations in local stiffness within soft tissue. Recent advances in ARFI beam sequencing and parallel imaging have shortened acquisition times and lessened transducer heating to a point where ARFI acquisitions can be executed at high frame rates on commercially available diagnostic scanners. In vivo ARFI images were acquired with a linear array placed on an exposed canine heart. The electrocardiogram (ECG) was also recorded. When coregistered with the ECG, ARFI displacement images of the heart reflect the expected myocardial stiffness changes during the cardiac cycle. A radio-frequency ablation was performed on the epicardial surface of the left ventricular free wall, creating a small lesion that did not vary in stiffness during a heartbeat, though continued to move with the rest of the heart. ARFI images showed a hemispherical, stiffer region at the ablation site whose displacement magnitude and temporal variation through the cardiac cycle were less than the surrounding untreated myocardium. Sequences with radiation force pulse amplitudes set to zero were acquired to measure potential cardiac motion artifacts within the ARFI images. The results show promise for real-time cardiac ARFI imaging. (E-mail: stephen.j.hsu@duke.edu) (c) 2007 World Federation for Ultrasound in Medicine & Biology.