Tumor progression and metastasis
Tumor progression and metastasis
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DOI：
10.1093/carcin/21.3.497
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发表时间：
2000-03-01
期刊：
影响因子：
4.7
通讯作者：
Yokota, J
中科院分区：
文献类型：
--
作者：
Yokota, J
现在人们普遍认为，癌症是由于细胞中遗传变异的积累。因此，为了理解癌症转移的分子机制，鉴定在癌症进展期间其改变积累的基因以及其表达负责在癌细胞中获得转移潜能的基因是必不可少的。对不同进展阶段的癌细胞的分子分析表明，肿瘤抑制基因和癌基因的改变在肿瘤进展过程中积累，并与癌症的临床侵袭性相关。转移性和非转移性细胞之间的基因表达谱的比较分析已经揭示了各种基因的差异表达与癌细胞的转移潜能相关。许多基因也已被鉴定为在实验模型中具有诱导或抑制转移的功能。然而，致病性遗传改变和由此产生的表型改变与癌细胞转移潜能之间的关联尚未完全了解。因此，需要阐明基因型-表型相关性，以进一步了解复杂的转移过程。本文就近20年来肿瘤进展和转移的分子生物学研究进展进行综述，并对该领域未来的研究方向进行探讨。
It is now widely accepted that cancer is attributed to the accumulation of genetic alterations in cells. Thus, to understand the molecular mechanisms of cancer metastasis, it is indispensable to identify the genes whose alterations accumulate during cancer progression as well as the genes whose expression is responsible for the acquisition of metastatic potential in cancer cells. Molecular analyses of cancer cells in various stages of progression have revealed that alterations in tumor suppressor genes and oncogenes accumulate during tumor progression and correlate with the clinical aggressiveness of cancer. Comparative analyses of gene expression profiles between metastatic and nonmetastatic cells have revealed that various genes are differentially expressed in association with the metastatic potential of cancer cells. A number of genes have been also identified as having functions in inducing or suppressing metastasis in experimental models. However, the association between causative genetic alterations and resulting phenotypic alterations with respect to the metastatic potential of cancer cells is not fully understood. Therefore, elucidation of genotype-phenotype correlation will be required to further understand a complex process of metastasis. Here, I review the progress on molecular studies of tumor progression and metastasis of the past 20 years and discuss the future direction in this field of science.