Pillbox organizers are associated with improved adherence to HIV antiretroviral therapy and viral suppression: A marginal structural model analysis
Pillbox organizers are associated with improved adherence to HIV antiretroviral therapy and viral suppression: A marginal structural model analysis
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DOI：
10.1086/521250
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发表时间：
2007-10-01
影响因子：
11.8
通讯作者：
Bangsberg, David R.
中科院分区：
文献类型：
--
作者：
Petersen, Maya L.;Wang, Yue;Bangsberg, David R.
背景。药盒盒价格低廉，使用方便；然而，它们对抗逆转录病毒药物依从性的影响尚不清楚。数据来自1996年至2000年在加州旧金山对245名人类免疫缺陷病毒（HIV）感染者的观察队列。依从性是主要结果，并使用未公布的每月药片计数进行测量。血浆HIV RNA水平被认为是次要结果。边际结构模型用于估计药盒整理剂对依从性和病毒抑制的影响，调整了CD4(+) T细胞计数、病毒载量、既往依从性、娱乐性药物使用、人口统计学特征以及当前和过去治疗的混杂因素。据估计，药丸盒组织者的使用使依从性提高了4.1%-4.5%，并与病毒载量降低0.34-0.37 log(10) copies/mL和达到病毒载量的可能性提高14.2%-15.7%相关
Background. Pillbox organizers are inexpensive and easily used; however, their effect on adherence to antiretroviral medications is unknown.Methods. Data were obtained from an observational cohort of 245 human immunodeficiency virus ( HIV) infected subjects who were observed from 1996 through 2000 in San Francisco, California. Adherence was the primary outcome and was measured using unannounced monthly pill counts. Plasma HIV RNA level was considered as a secondary outcome. Marginal structural models were used to estimate the effect of pillbox organizer use on adherence and viral suppression, adjusting for confounding by CD4(+) T cell count, viral load, prior adherence, recreational drug use, demographic characteristics, and current and past treatment.Results. Pillbox organizer use was estimated to improve adherence by 4.1%-4.5% and was associated with a decrease in viral load of 0.34-0.37 log(10) copies/mL and a 14.2%-15.7% higher probability of achieving a viral load