Circulating heat-shock protein 70 is associated with postoperative infection and organ dysfunction after liver resection
Circulating heat-shock protein 70 is associated with postoperative infection and organ dysfunction after liver resection
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DOI：
10.1016/j.amjsurg.2003.08.029
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发表时间：
2004-06-01
影响因子：
3
通讯作者：
Miyazaki, M
中科院分区：
文献类型：
--
作者：
Kimura, F;Itoh, H;Miyazaki, M
背景资料：虽然细胞外热休克蛋白70（Hsp 70）可能介导炎症反应，但循环中Hsp 70与术后并发症的关系尚不清楚。方法：采用免疫测定法测定64例连续肝切除患者围手术期血浆Hsp 70和白细胞介素6浓度。Hsp 70和白细胞介素-6的血浆浓度在手术后立即和术后第1天显著增加。Hsp 70水平与手术时间、肝缺血时间、术后丙氨酸氨基转移酶水平和最大白细胞介素6水平显著相关（P
Background: Although extracellular heat-shock protein 70 (Hsp70) potentially mediates an inflammatory response, the association of circulating Hsp70 with complications after surgery is poorly understood.Methods: Perioperative plasma concentrations of Hsp70 and interleukin-6 were measured by immumoassays in 64 consecutive patients undergoing liver resection.Results: Plasma concentrations of Hsp70 and interleukin-6 showed a striking increase immediately after surgery, and on postoperative day 1. The Hsp70 levels correlated significantly with operation time, hepatic ischemia time, postoperative alanine aminotransferase levels, and maximum interleukin-6 levels (P