Effects of Locomotion Extend throughout the Mouse Early Visual System
Effects of Locomotion Extend throughout the Mouse Early Visual System
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DOI：
10.1016/j.cub.2014.10.045
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发表时间：
2014-12-01
期刊：
影响因子：
9.2
通讯作者：
Busse, Laura
中科院分区：
文献类型：
--
作者：
Erisken, Sinem;Vaiceliunaite, Agne;Busse, Laura
背景：视皮层的神经反应不仅依赖于感觉输入，而且依赖于行为环境。其中一个背景是运动，它调节初级视觉皮层（V1）中的单神经元活动。运动如何影响神经元群体在皮层层和皮层前结构是不是很好地understood.Results：我们进行细胞外多电极记录在视觉系统的小鼠在运动和静止期。我们发现，运动的影响活动的V1神经元的特征层配置文件和形状的人口反应，减少成对的相关性。虽然减少成对的相关性仅限于皮质，运动轻微，但一贯增加发射率和控制调谐选择性已经在背外侧膝状体核（dLGN）的丘脑。在眼睛的水平，运动速度的增加与瞳孔dilation.Conclusions：这些研究结果文件进一步，非倍增效应的运动，达到较早的处理阶段比皮层。
Background: Neural responses in visual cortex depend not only on sensory input but also on behavioral context. One such context is locomotion, which modulates single-neuron activity in primary visual cortex (V1). How locomotion affects neuronal populations across cortical layers and in precortical structures is not well understood.Results: We performed extracellular multielectrode recordings in the visual system of mice during locomotion and stationary periods. We found that locomotion influenced activity of V1 neurons with a characteristic laminar profile and shaped the population response by reducing pairwise correlations. Although the reduction of pairwise correlations was restricted to cortex, locomotion slightly but consistently increased firing rates and controlled tuning selectivity already in the dorsolateral geniculate nucleus (dLGN) of the thalamus. At the level of the eye, increases in locomotion speed were associated with pupil dilation.Conclusions: These findings document further, nonmultiplicative effects of locomotion, reaching earlier processing stages than cortex.