Normal P50 suppression in schizophrenia patients treated with atypical antipsychotic medications
Normal P50 suppression in schizophrenia patients treated with atypical antipsychotic medications
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DOI：
10.1176/appi.ajp.157.5.767
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发表时间：
2000-05-01
影响因子：
17.7
通讯作者：
Braff, DL
中科院分区：
文献类型：
--
作者：
Light, GA;Geyer, MA;Braff, DL
目的：精神分裂症患者存在注意力、认知和信息加工方面的缺陷。P50抑制等措施被用于研究这些患者的认知和注意力功能障碍。P50抑制是一种感觉门控的操作测量，可以通过对间隔500毫秒的多对听觉滴答声的平均脑电图反应来评估。正常情况下，P50对第二次点击的响应小于对第一次点击的响应。许多研究表明，精神分裂症患者有P50抑制缺陷，这意味着第一次和第二次点击之间的差异没有正常人那么大。非典型抗精神病药物对阴性症状和认知缺陷可能有较好的临床疗效。因此，评估非典型抗精神病药物对P50抑制等措施的影响非常重要。方法：比较13例精神分裂症患者临床有效剂量氯氮平、奥氮平或利培酮（归类为非典型抗精神病药物）与13例常规抗精神病药物的P50抑制情况。结果：患者组在临床或人口学指标上没有差异。接受非典型抗精神病药物治疗的患者P50抑制在正常范围（平均72%）。相比之下，接受典型抗精神病药物治疗的患者P50抑制显著降低（平均= 27%）。结论：研究结果支持了接受非典型抗精神病药物治疗的患者感觉门控P50测量正常的假设。有必要对受试者进行纵向研究，以阐明介导这种效应的机制。
Objective: Patients with schizophrenia have deficits in attention, cognition, and information processing. Measures such as P50 suppression are used to study cognitive and attentional dysfunction among these patients. P50 suppression is an operational measure of sensory gating that can be assessed by averaging electroencephalographic responses to multiple pairs of auditory clicks separated by 500 msec. Normally, the P50 response to the second click is smaller than the response to the first click. Many studies have demonstrated that schizophrenia patients have deficient P50 suppression, meaning that the difference between the first and second clicks is not as large as normal. Atypical antipsychotic medications may have superior clinical efficacy for negative symptoms and cognitive deficits. It is important, therefore, to evaluate the effects of atypical antipsychotic medications on measures such as P50 suppression.Method: P50 suppression of 13 patients with schizophrenia receiving clinically effective doses of clozapine, olanzapine, or risperidone (classified as atypical antipsychotic medications) was compared to that of 13 patients receiving conventional antipsychotic medications.Results: The patient groups did not differ on clinical or demographic measures. The patients receiving atypical antipsychotic medications had normal-range P50 suppression (mean=72%). In contrast, the patients receiving typical antipsychotic medications had dramatically lower P50 suppression (mean= 27%).Conclusions: The results support the hypothesis that patients treated with atypical antipsychotic medications have normal P50 measures of sensory gating. Longitudinal within-subjects studies are warranted to clarify the mechanisms mediating this effect.