The bacterial and host factors associated with extrapulmonary dissemination of Mycobacterium tuberculosis.
The bacterial and host factors associated with extrapulmonary dissemination of Mycobacterium tuberculosis.
复制标题
与结核分枝杆菌肺外传播相关的细菌和宿主因素。
DOI：
10.1007/s11515-015-1358-y
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Kong,Ying
中科院分区：
文献类型：
--
作者：
Yang,Dong;Kong,Ying
结核病在全球范围内的发病率和死亡率都很高，仍然是一个重要的公共卫生威胁。大多数人类结核病病例是由结核分枝杆菌引起的。虽然肺结核是最常见的表现，M。结核病可以扩散到其他器官，引起肺外结核（EPTB）。细菌从最初的感染部位传播到其他器官可能导致致命的疾病，如粟粒性和脑膜结核病。彻底了解传播的机制和途径将开发预防EPTB（粟粒性和脑膜结核）致命预后的疗法和促进适应性免疫发展的疫苗。本文就EPTB的危险因素、与EPTB相关的细菌和宿主基因以及M.肺外播散
With high morbidity and mortality worldwide, tuberculosis (TB) is still an important public health threat. The majority of human TB cases are caused byMycobacterium tuberculosis. Although pulmonary TB is the most common presentation,M. tuberculosiscan disseminate into other organs and causes extrapulmonary TB (EPTB). The dissemination of bacteria from the initial site of infection to other organs can lead to fatal diseases, such as miliary and meningeal TB. Thoroughly understanding the mechanisms and pathways of dissemination would develop therapies to prevent the lethal prognosis of EPTB (miliary and meningeal TB) and vaccines to promote the development of adaptive immunity. This review focuses on risk factors of EPTB, bacterial and host genes involved in EPTB, and potential mechanisms ofM. tuberculosisextrapulmonary dissemination.