Integrin alpha(v)beta3 promotes M21 melanoma growth in human skin by regulating tumor cell survival.
Integrin alpha(v)beta3 promotes M21 melanoma growth in human skin by regulating tumor cell survival.
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发表时间：
1999
期刊：
影响因子：
11.2
通讯作者：
E. Petitclerc;S. Strömblad;T. Von Schalscha;F. Mitjans;J. Piulats;A. Montgomery;D. Cheresh;P. Brooks-P.
中科院分区：
文献类型：
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作者：
E. Petitclerc;S. Strömblad;T. Von Schalscha;F. Mitjans;J. Piulats;A. Montgomery;D. Cheresh;P. Brooks-P.
恶性黑色素瘤的生长和传播对我们的人口产生深远的影响，但人们对人类控制这种疾病的机制知之甚少。有证据表明，整合素 α(v)β3 通过独立于其在血管生成中的已知作用的机制，在人类皮肤内的 M21 黑色素瘤肿瘤存活中发挥着关键作用。 α(v)β3 拮抗剂通过诱导肿瘤细胞凋亡来阻止黑色素瘤生长。此外，M21 黑色素瘤细胞与变性胶原蛋白（一种已知的 α(v)beta3 配体）相互作用，导致相对 Bcl-2:Bax 比率增加 5 倍，这一事件被认为可以促进细胞存活。重要的是，在人类肿瘤活检中，变性胶原蛋白与表达α(v)β3的黑色素瘤细胞共定位，这表明α(v)β3与变性胶原蛋白的相互作用可能在体内黑色素瘤肿瘤的存活中发挥关键作用。
Growth and dissemination of malignant melanoma has a profound impact on our population, and little is known concerning the mechanisms controlling this disease in humans. Evidence is provided that integrin alpha(v)beta3 plays a critical role in M21 melanoma tumor survival within human skin by a mechanism independent of its known role in angiogenesis. Antagonists of alpha(v)beta3 blocked melanoma growth by inducing tumor apoptosis. Moreover, M21 melanoma cell interactions with denatured collagen, a known ligand for alpha(v)beta3, caused a 5-fold increase in the relative Bcl-2:Bax ratio, an event thought to promote cell survival. Importantly, denatured collagen colocalized with alpha(v)beta3-expressing melanoma cells in human tumor biopsies, suggesting that alpha(v)beta3 interaction with denatured collagen may play a critical role in melanoma tumor survival in vivo.