Excessive sodium ions delivered into cells by nanodiamonds: implications for tumor therapy.
Excessive sodium ions delivered into cells by nanodiamonds: implications for tumor therapy.
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DOI：
10.1002/smll.201102539
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发表时间：
2012-06
期刊：
影响因子：
13.3
通讯作者：
Ying Zhu;Wenxin Li;Yu Zhang;Jing Li;Le Liang;Xiangzhi Zhang;Nan Chen;Yanhong Sun;Wen Chen;R. Tai;C. Fan;Qing Huang
中科院分区：
文献类型：
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作者：
Ying Zhu;Wenxin Li;Yu Zhang;Jing Li;Le Liang;Xiangzhi Zhang;Nan Chen;Yanhong Sun;Wen Chen;R. Tai;C. Fan;Qing Huang
纳米金刚石（ND）具有许多优异的物理和化学性质，使其成为生物医学应用的有吸引力的材料。在本文中，大量的钠离子的吸附和输送到细胞内部的无血清培养基中的ND证明。细胞内过量的钠离子诱导渗透压，随后是细胞肿胀和细胞内钙和活性氧（ROS）水平的增加，这导致严重的细胞损伤。然而，在完全培养基中，包裹在ND周围的血清蛋白有效地防止钠离子吸附到ND上，因此ND不显示细胞毒性。这项工作是第一次详细阐述钠离子吸附在纳米材料和它们的生物效应之间的相关性。通过核聚变向细胞内输送过量的离子可能在肿瘤治疗中具有潜在的应用价值。
Nanodiamonds (NDs) possess many excellent physical and chemical properties that make them attractive materials for applications in biomedicine. In this paper, the adsorption and delivery of a large amount of sodium ions into the cell interior by NDs in serum-free medium is demonstrated. The excess sodium ions inside the cells induce osmotic stresses followed by cell swelling and an increase in the intracellular levels of calcium and reactive oxygen species (ROS), which leads to severe cellular damage. In complete culture medium, however, serum proteins wrapped around the NDs effectively prevent the sodium ions from adsorbing onto the NDs, and thus the NDs show no cytotoxicity. This work is the first to elaborate on the correlation between the sodium ions adsorbed on the nanomaterials and their bio-effects. Excessive ions delivered into cells by NDs might have potential applications in tumor therapy.