Perspectives on the Next Generation of Sunscreen: Safe, Broadband, and Long-Term Photostability
Perspectives on the Next Generation of Sunscreen: Safe, Broadband, and Long-Term Photostability
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下一代防晒霜的展望：安全、宽带和长期光稳定性
DOI：
10.1021/acsmaterialslett.9b00203
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发表时间：
2019
影响因子：
11.4
通讯作者：
Lu Qinghua
中科院分区：
文献类型：
--
作者：
Dong Yuan;Chen Shuangshuang;Zhou Shiliu;Hou Shenglei;Lu Qinghua
尽管防晒剂的迅速发展和广泛商业化，但关于商业防晒剂的生物相容性和功效的挑战仍然存在。直接暴露于紫外线过滤剂已经引起健康问题，包括经皮渗透和活性氧的产生。为了解决这些问题，我们开发了有机紫外线过滤自框架微粒，其中有机紫外线过滤分子自构建成纳米颗粒，而无需任何支持性微胶囊化。这种方法是独特的，因为它通过减少有机紫外线过滤分子的经皮渗透而具有出色的生物相容性。此外，通过引入物理反射效应，屏蔽范围从UVB扩展到整个UV区域。体外成纤维细胞培养实验和体内皮肤保护实验的结果证实了它们的安全性。实验结果支持了自框架微粒防晒霜（FSFMPs）具有较好的防晒效果的结论。
Despite the burgeoning development and extensive commercialization of sunscreens, challenges remain regarding the biocompatibility and efficacy of commercial sunscreens. Direct exposure to UV filters has given rise to health problems, including the percutaneous penetration and the generation of reactive oxygen species. To address these, we have developed organic UV-filter self-framed microparticles, whereby organic UV-filter molecules self-construct into nanoparticles without any supportive microencapsulation. This approach is unique for its outstanding biocompatibility by reducing the percutaneous penetration of organic UV-filter molecules. Furthermore, the shielding range is extended from the UVB to the entire UV region by the introduction of a physical reflection effect. An in vitro fibroblast culture experiment and the results of in vivo skin protection experiments confirmed their safety. All the experimental results supported the conclusion that sunblock with self-framed microparticles (FSFMPs) has a...