Hedgehog, transmitted along retinal axons, triggers neurogenesis in the developing visual centers of the Drosophila brain
Hedgehog, transmitted along retinal axons, triggers neurogenesis in the developing visual centers of the Drosophila brain
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DOI：
10.1016/s0092-8674(00)80114-2
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发表时间：
1996-08-09
期刊：
影响因子：
64.5
通讯作者：
Kunes, S
中科院分区：
文献类型：
--
作者：
Huang, Z;Kunes, S
果蝇大脑视觉中心的发育受到发育中眼睛的视网膜轴突的严密调控。在第一个视神经节中，到达视网膜轴突的板层触发它们的突触伙伴的前体完成最终的细胞分裂并开始神经分化。Hedgehog基因的分泌产物调节复眼中光感受器前体细胞在时间上组装成小眼群。在这里，我们展示了Hedgehog是沿着视网膜轴突传递的，作为大脑中的感应信号。Hedgehog在视网膜轴突介导的板层突触小盒组装的两个步骤中的第一步起作用。这些观察为协调神经前体细胞组装成精确突触电路的分子相互作用提供了新的见解。
The development of the visual centers of the Drosophila brain is tightly regulated by the ingrowth of retinal axons from the developing eye. In the first optic ganglion, the lamina, arriving retinal axons trigger the precursors of their synaptic partners to complete a final cell division and commence neural differentiation. The secreted product of the hedgehog gene regulates the temporal assembly of photoreceptor precursor cells into ommatidial clusters in the compound eye. Here, we show that Hedgehog is transmitted along the retinal axons to serve as the inductive signal in the brain. Hedgehog acts in the first of two retinal axon-mediated steps in the assembly of lamina synaptic cartridges. These observations provide a novel insight into the molecular interactions that orchestrate the assembly of neural precursor cells into precise synaptic circuits.