Neuropilin signalling in angiogenesis
Neuropilin signalling in angiogenesis
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DOI：
10.1042/bst20110689
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发表时间：
2012-02-01
影响因子：
3.9
通讯作者：
Koch, Sina
中科院分区：
文献类型：
--
作者：
Koch, Sina
VEGF（血管内皮生长因子）是成人健康和疾病期间血管发育以及血液和淋巴管功能的主要调节因子。这个由五个哺乳动物配体组成的家族通过三个 RTK（受体酪氨酸激酶）发挥作用。此外，NRP（神经毡蛋白）等共受体与配体-受体信号复合物结合并调节输出。已经开发出阻断几种 VEGF 信号传导成分以及 NRP 功能的疗法，目的是在涉及组织生长和炎症的疾病（例如癌症）中阻止血管形成和血管生成。本综述概述了目前对 NRP 与血液和淋巴管生物学相关的理解。
VEGFs (vascular endothelial growth factors) are master regulators of vascular development and of blood and lymphatic vessel function during health and disease in adults. This family of five mammalian ligands acts through three RTKs (receptor tyrosine kinases). In addition, co-receptors such as NRPs (neuropilins) associate with the ligand-receptor signalling complex and modulate the output. Therapeutics to block several of the VEGF signalling components as well as NRP function have been developed with the aim of halting blood vessel formation, angiogenesis, in diseases that involve tissue growth and inflammation, such as cancer. The present review outlines the current understanding of NRPs in relation to blood and lymphatic vessel biology.