Synergy of herbal ingredients combination against Dactylogyrus spp. in an infected goldfish model for monogenean management
Synergy of herbal ingredients combination against Dactylogyrus spp. in an infected goldfish model for monogenean management
复制标题
草药成分组合对抗指环菌的协同作用。
DOI：
10.1016/j.aquaculture.2014.05.045
复制
发表时间：
2014-09-20
期刊：
影响因子：
4.5
通讯作者：
Wang, Gao-Xue
中科院分区：
文献类型：
--
作者：
Jiang, Chao;Wu, Zhuo-Qi;Wang, Gao-Xue
目前针对指环虫的单组分化疗效果不理想，且存在抗药性和药物残留等副作用。本研究在活体条件下研究了中草药成分组合对鲫鱼指环虫的防治效果。对盾叶薯蓣（D.zingiberensis，D. zingiberensis）和银杏（Ginkgo biloba（G. biloba）在本研究的实验鱼感染模型中单独和组合施用。最后，在甲醇提取物组合和活性化合物组合中观察到D. zingiberensis和G. biloba.该组合的驱虫效果以EC50、EC75、EC90和EC99的值表示，以与单独的植物药物进行比较。还通过使用组合指数算法来计算组合指数（CI）。有效浓度和联合指数值均表明对指环虫具有高度协同驱虫作用。我们的研究提供了一个强有力的手段，通过它可以检查驱虫组合疗法，并证明了草药成分的组合具有优良的性能，并预测在水产养殖的单殖吸虫管理中提高治愈率。(C)2014爱思唯尔有限公司版权所有。
Current chemotherapy of mono-component for Dactylogyrus is unsatisfactory due to its limited efficacy with side effects including pesticide resistance and drug residue. The present study is conducted to investigate the effects of herbal ingredients combination against Dactylogyrus on Carassius auratus under in vivo conditions. The ingredients of Dioscorea zingiberensis (D. zingiberensis) and Ginkgo biloba (G. biloba) are administered individually and in combination in an experimental fish infection model in this study. Finally, strong synergy actions are observed in both the methanol extract combinations and the active compound combinations between D. zingiberensis and G. biloba. The anthelmintic effects of the combination are expressed in terms of the values of EC50, EC75, EC90, and EC99 to compare with the phytomedicine alone. The combination index (CI) is also calculated by using the combination index algorithm. Both the values of effective concentration and combination index indicate a highly synergistic anthelmintic effect against Dactylogyrus. Our study provides a powerful means by which anthelmintic combination therapies can be examined and demonstrates that the combinations of herbal ingredients have excellent properties and are predicted to give improved cure rates in monogenean management of aquaculture. (C) 2014 Elsevier B.V. All rights reserved.