Revisiting the mouse model of oxygen-induced retinopathy.
Revisiting the mouse model of oxygen-induced retinopathy.
复制标题
重新访问氧诱导的视网膜病的小鼠模型。
作者：
Kim CB;D'Amore PA;Connor KM
视网膜血管异常生长是许多视网膜疾病的标志，如早产儿视网膜病变（ROP）、增殖性糖尿病视网膜病变和湿型老年性黄斑变性。特别是，自从70多年前早产儿常规补充氧治疗出现以来，ROP一直是医生关注的一个重要健康问题。从那时起，研究人员探索了几种动物模型，以更好地了解ROP和视网膜血管发育。在这些模型中，氧诱导视网膜病变（OIR）小鼠模型已成为应用最广泛的模型，并在我们对视网膜血管生成和眼免疫学的理解以及开发突破性治疗方法（如抗血管内皮生长因子注射治疗湿性年龄相关性黄斑变性）方面发挥了关键作用。自20世纪50年代该模型诞生以来，人们对其进行了多次改进，技术进步也扩大了该模型在多个科学领域的应用。在这篇综述中，我们探讨了导致今天使用的小鼠OIR模型的历史发展，OIR的基本概念，模型的局限性，并从OIR中选择了具有代表性的关键发现，特别强调了当前的研究进展。
Abnormal blood vessel growth in the retina is a hallmark of many retinal diseases, such as retinopathy of prematurity (ROP), proliferative diabetic retinopathy, and the wet form of age-related macular degeneration. In particular, ROP has been an important health concern for physicians since the advent of routine supplemental oxygen therapy for premature neonates more than 70 years ago. Since then, researchers have explored several animal models to better understand ROP and retinal vascular development. Of these models, the mouse model of oxygen-induced retinopathy (OIR) has become the most widely used, and has played a pivotal role in our understanding of retinal angiogenesis and ocular immunology, as well as in the development of groundbreaking therapeutics such as anti-vascular endothelial growth factor injections for wet age-related macular degeneration. Numerous refinements to the model have been made since its inception in the 1950s, and technological advancements have expanded the use of the model across multiple scientific fields. In this review, we explore the historical developments that have led to the mouse OIR model utilized today, essential concepts of OIR, limitations of the model, and a representative selection of key findings from OIR, with particular emphasis on current research progress.