Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41
Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41
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DOI：
10.1073/pnas.2637002100
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发表时间：
2004-01-27
影响因子：
11.1
通讯作者：
Yanagisawa, M
中科院分区：
文献类型：
--
作者：
Xiong, YM;Miyamoto, N;Yanagisawa, M
瘦素是一种脂肪源性激素，调节多种生理过程，包括摄食行为、代谢率、交感神经活动、生殖和免疫反应。循环中的瘦素水平根据体内能量稳态而受到严格调节。虽然脂肪细胞中瘦素产生的调节机制还不清楚，但G蛋白偶联受体可能在脂肪细胞的这一功能中发挥重要作用。在这里，我们报告说，C2-C6短链脂肪酸，孤儿G蛋白偶联受体GPR 41的配体，刺激瘦素在小鼠脂肪细胞系和小鼠脂肪组织的原代培养表达。急性口服丙酸盐增加小鼠循环瘦素水平。刺激瘦素产生所需的短链脂肪酸的浓度在生理范围内，表明该途径在体内的相关性。
Leptin is an adipose-derived hormone that regulates a wide variety of physiological processes, including feeding behavior, metabolic rate, sympathetic nerve activity, reproduction, and immune response. Circulating leptin levels are tightly regulated according to energy homeostasis in vivo. Although mechanisms for the regulation of leptin production in adipocytes are not well understood, G protein-coupled receptors may play an important role in this adipocyte function. Here we report that C2-C6 short-chain fatty acids, ligands of an orphan G protein-coupled receptor GPR41, stimulate leptin expression in both a mouse adipocyte cell line and mouse adipose tissue in primary culture. Acute oral administration of propionate increases circulating leptin levels in mice. The concentrations of short-chain fatty acids required to stimulate leptin production are within physiological ranges, suggesting the relevance of this pathway in vivo.