Parental smoking and airway reactivity in healthy infants
Parental smoking and airway reactivity in healthy infants
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DOI：
10.1164/rccm.200406-711oc
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发表时间：
2005-01-01
影响因子：
24.7
通讯作者：
Daggy, J
中科院分区：
文献类型：
--
作者：
Tepper, RS;Williams-Nkomo, T;Daggy, J
父母吸烟与婴儿气道功能降低和喘息性呼吸道疾病发病率增加有关。我们在76名健康婴儿中评估了父母吸烟是否与气道高反应性相关，这可能导致气道功能降低和喘息性疾病增加。使用快速胸外按压技术测量气道功能，并通过乙酰甲胆碱激发（0.015-10 mg/ml）评估气道反应性，当用力呼气流量（FEF）下降超过30%时停止激发（75），或当末次剂量下降小于30%时停止激发（75）。父母吸烟与基线气道功能较低相关（FEF 50，600 vs. 676 ml/s，p < 0.04; FEF 25 -75，531 vs. 597 ml/s，p < 0.05）。暴露于吸烟的婴儿在任何乙酰甲胆碱剂量下FEF 75下降超过30%的可能性约为一半（风险比= 0.4，p = 0.001）。此外，大家庭成员中的哮喘史增加了婴儿FEF 75下降超过30%的可能性（风险比= 1.7，p = 0.04）。我们的结论是，父母吸烟与气道功能降低有关，但与气道反应性增加无关;然而，哮喘家族史与气道反应性增加有关。
Parental tobacco smoking is associated with lower airway function and an increased incidence of wheezy respiratory illnesses in infants. We evaluated in 76 healthy infants whether exposure to parental tobacco smoking was associated with airway hyperreactivity, which could contribute to lower airway function and the increased wheezy illnesses. Airway function was measured using the raised-volume rapid thoracic compression technique, and airway reactivity was assessed by methacholine challenge (0.015-10 mg/ml), which was stopped for a more than 30% decrease in forced expiratory flow (FEF)(75) or the final dose with a less than 30% decrease. Parental tobacco smoking was associated with lower baseline airway function (FEF50, 600 vs. 676 ml/second, p < 0.04; FEF25-75, 531 vs. 597 ml/second, p < 0.05). Infants exposed to tobacco smoking were approximately half as likely to develop a more than 30% decline in FEF75 at any given methacholine dose (hazard ratio = 0.4, p = 0.001). In addition, a history of asthma in an extended family member increased the likelihood that an infant would develop a more than 30% decline in FEF75 (hazard ratio = 1.7, p = 0.04). We conclude that exposure to parental smoking is associated with lower airway function but not increased airway reactivity; however, family history of asthma is associated with heightened airway reactivity.