Increasing prevalence of toxin A-negative, toxin B-positive isolates of Clostridium difficile in Korea:: Impact on laboratory diagnosis
Increasing prevalence of toxin A-negative, toxin B-positive isolates of Clostridium difficile in Korea:: Impact on laboratory diagnosis
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DOI：
10.1128/jcm.01188-07
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发表时间：
2008-03-01
影响因子：
9.4
通讯作者：
Park, Jong-Woo
中科院分区：
文献类型：
--
作者：
Kim, Heejung;Riley, Thomas V.;Park, Jong-Woo
在462株韩国艰难梭菌分离株中，77.5%为毒素B阳性，但21.4%为毒素A阴性（A（-）B（+））。在9个分离株中检测到二元毒素基因。A（-）B（+）菌株对氟喹诺酮类药物的耐药性增高可能是导致A（-）B（+）菌株耐药性增高的原因之一。单独检测毒素A可能会低估C。艰难梭相关疾病
Of 462 Korean Clostridium difficile isolates, 77.5% were toxin B positive but 21.4% were toxin A negative (A(-)B(+)). The binary toxin gene was detected in nine isolates. A higher fluoroquinolone resistance of A(-)B(+) strains may contribute to the increase of these strains. Toxin A detection alone may underdiagnose C. difficile-associated disease.