Dynamic selection of novel vancomycin N-terminal derivatives by resin-bound reversed D-Ala-D-Ala.
Dynamic selection of novel vancomycin N-terminal derivatives by resin-bound reversed D-Ala-D-Ala.
复制标题
通过树脂结合的反向 D-Ala-D-Ala 动态选择新型万古霉素 N 末端衍生物。
DOI：
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发表时间：
2008
影响因子：
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通讯作者：
Gang Liu
中科院分区：
文献类型：
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作者：
Yu;Wenhuan He;Yan Wu;Changqun Niu;Gang Liu
动态组合化学(DCC)最吸引人的优点是它可以在化合物合成后立即筛选化合物文库。然而，使用最先进的分析技术来分析带有自由探针的动态组合库是非常困难的。我们在这里报告了一种使用树脂固定的反转肽探针来筛选万古霉素衍生物的方法，并提供了这个问题的解决方案。
The most attractive advantage of dynamic combinatorial chemistry (DCC) is that it can screen the compound library as soon as compounds are synthesized. However, it is very difficult to analyze a dynamic combinatorial library with free probes using the state-of-the art analysis technologies. We report herein a method that uses a resin-immobilizing reversed peptide probe to screen vancomycin derivatives and provides a solution to this problem.