Aureochaeglobosins A-C, Three [4 + 2] Adducts of Chaetoglobosin and Aureonitol Derivatives from Chaetomium globosum.
Aureochaeglobosins A-C, Three [4 + 2] Adducts of Chaetoglobosin and Aureonitol Derivatives from Chaetomium globosum.
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DOI：
10.1021/acs.orglett.8b01243
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发表时间：
2018-05
期刊：
影响因子：
5.2
通讯作者：
Ming-Hua Yang;M. Gu;Chao Han;Xiao-Jiang Guo;Guo-Ping Yin;Pei Yu;L. Kong
中科院分区：
文献类型：
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作者：
Ming-Hua Yang;M. Gu;Chao Han;Xiao-Jiang Guo;Guo-Ping Yin;Pei Yu;L. Kong
金毛球菌素 A-C (1-3) 是毛球菌素和金黄色素醇衍生物的三种新型 [4 + 2] 环加成异二聚体，是从内生真菌球毛壳菌培养物中获得的，代表了毛球菌素的第一个加合物实例。通过广泛的光谱分析、单晶 X 射线衍射和改进的 Mosher 方法阐明了它们的结构。化合物2和3对人MDA-MB-231癌细胞表现出显着的细胞毒性，IC50值分别为7.6和10.8 μM。
Aureochaeglobosins A-C (1-3), three novel [4 + 2] cycloaddition heterodimers of chaetoglobosin and aureonitol derivatives, were obtained from the culture of endophytic fungus Chaetomium globosum, representing the first adduct examples of chaetoglobosins. Their structures were elucidated by extensive spectroscopic analyses, single-crystal X-ray diffraction, and a modified Mosher's method. Compounds 2 and 3 showed significant cytotoxicities against human MDA-MB-231 cancer cells with IC50 values of 7.6 and 10.8 μM, respectively.