The role of natural killer cells in pulmonary immunosurveillance.
The role of natural killer cells in pulmonary immunosurveillance.
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DOI：
10.2741/s391
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发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Krupnick AS
中科院分区：
文献类型：
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作者：
Hesker PR;Krupnick AS
自然杀伤（NK）细胞最初被确定为能够杀死癌细胞的淋巴细胞，而无需事先致敏。这些细胞在人类和啮齿动物模型中的进一步表征扩大了它们在患病和健康外周组织的广泛免疫监测中的作用。在周围器官中，肺中NK细胞的比例最大。因此，NK细胞参与了肺内的许多免疫反应，包括先天效应功能以及适应性免疫反应的启动。在这篇文章中，我们综述了NK细胞的特性，目前NK成熟和细胞活化的模型，NK向肺的迁移，以及NK在癌症和气道感染中的效应功能。特别强调了NKs在癌症免疫监测中的功能意义。NK细胞的治疗性调节似乎是一种具有挑战性但有希望的方法来限制癌症，炎症和肺部感染。
Natural killer (NK) cells were originally identified as lymphocytes capable of killing cancer cells without prior sensitization. Further characterization of these cells in both humans and rodent models has expanded their role towards a broad-based immunosurveillance of diseased and healthy peripheral tissues. Among peripheral organs, the lung contains the largest percentage of NK cells. Accordingly, NK cells are implicated in many immunological responses within the lung, including innate effector functions as well as initiation of the adaptive immune response. In this article, we review the characteristics of NK cells, current models of NK maturation and cell activation, migration of NKs to the lung, and effector functions of NKs in cancer and infection in the airways. Specific emphasis is placed on the functional significance of NKs in cancer immunosurveillance. Therapeutic modulation of NK cells appears to be a challenging but promising approach to limit cancer, inflammation, and infection in the lung.