Correlation between In Vitro Cytotoxicity and Octanol/Water Partition Coefficient of 29 Substances from the MEIC Programme
Correlation between In Vitro Cytotoxicity and Octanol/Water Partition Coefficient of 29 Substances from the MEIC Programme
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MEIC 计划中 29 种物质的体外细胞毒性与辛醇/水分配系数之间的相关性
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
H. Spielmann
中科院分区：
文献类型：
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作者：
W. Halle;I. Baeger;B. Ekwall;H. Spielmann
对MEIC（体外细胞毒性多中心评价）项目的化学品进行单线性回归分析，以获得根据文献数据在各种试验系统中测定的体外细胞毒性与其亲脂性之间的相关性。测定了29种MEIC物质的IC 50 x <$'值（每种物质两个或多个IC 50值的几何平均值）与其辛醇/水分配系数（owp）之间的线性相关系数为0.76。由于MEIC物质选自广泛的结构上不相关的化学品类别，因此可以根据其owp系数对化学品的一般体外细胞毒性进行密切预测。
Single linear regression analysis was used for chemicals of the MEIC (multicentre evaluation of in vitro cytotoxicity) project, to obtain a correlation between in vitro cytotoxicity determined in various test systems, according to data from the literature, and their lipophilicity. A linear correlation coefficient of 0.76 was determined between the IC50x¯ values (geometrical mean of two or more IC50 values per substance) of 29 MEIC substances and their octanol/water partition coefficient (owp). Since the MEIC substances were selected from a broad spectrum of structurally unrelated classes of chemicals, it may be possible to make close predictions of the general in vitro cytotoxicities of chemicals from their owp coefficients.