Distinct tubulin dynamics in cancer cells explored using a highly tubulin-specific fluorescent probe
Distinct tubulin dynamics in cancer cells explored using a highly tubulin-specific fluorescent probe
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使用高度微管蛋白特异性荧光探针探索癌细胞中独特的微管蛋白动力学
DOI：
10.1039/c5cc04927j
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发表时间：
2015-01-01
影响因子：
4.9
通讯作者：
Bu，Xianzhang
中科院分区：
文献类型：
--
作者：
Zhu，Cuige;Zuo，Yinglin;Bu，Xianzhang
发现了一种高度特异性的荧光探针（OC 9），其表现出微管蛋白特异性的亲和荧光，其允许选择性标记微管中的细胞微管蛋白。此外，通过OC 9染色首次直接观察到不同细胞生物环境中的不同微管蛋白动力学，例如耐药或上皮-间质转化（EMT）癌细胞。
A highly specific fluorescent probe (OC9) was discovered exhibiting tubulin-specific affinity fluorescence, which allowed selective labeling of cellular tubulin in microtubules. Moreover, distinct tubulin dynamics in various cellular bio-settings such as drug resistant or epithelial-mesenchymal transition (EMT) cancer cells were directly observed for the first time via OC9 staining.