Naloxone-induced dissociation of oxytocin and prolactin releases.
Naloxone-induced dissociation of oxytocin and prolactin releases.
复制标题
纳洛酮诱导催产素和催乳素释放的解离。
DOI：
10.1159/000124053
复制
发表时间：
1985
影响因子：
4.1
通讯作者：
Lumpkin,MD
中科院分区：
文献类型：
--
作者：
Samson,WK;McDonald,JK;Lumpkin,MD
固定的成年雄性大鼠导致伴随的，显着的催乳素（PRL）和催产素（OT）的释放。纳洛酮（0.2mg/kg，i. p.）在开始束缚前30分钟给药导致PRL对应激的反应显著减少。另一方面，观察到OT释放的显著增加。这些结果表明，伴随释放的OT和PRL在一个给定的生理刺激（压力）可以被分离，并建议下丘脑事件，负责这些激素的释放在压力是不同的。
Immobilization of adult male rats resulted in concomitant, significant releases of prolactin (PRL) and oxytocin (OT). Naloxone (0.2 mg/kg, i.p.) administration 30 min prior to initiation of restraint resulted in a significant diminution of the PRL response to stress. On the other hand, a significant augmentation of OT release was observed. These results demonstrate that concomitant releases of OT and PRL in response to a given physiologic stimulus (stress) can be dissociated and suggest that the hypothalamic events which are responsible for the release of these hormones during stress are different.