EFFECT OF DIFFERENT INSULIN ADMINISTRATION MODALITIES ON VITAMIN-D METABOLISM OF INSULIN-DEPENDENT DIABETIC-PATIENTS
EFFECT OF DIFFERENT INSULIN ADMINISTRATION MODALITIES ON VITAMIN-D METABOLISM OF INSULIN-DEPENDENT DIABETIC-PATIENTS
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DOI：
10.1055/s-2007-1009144
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发表时间：
1989-01-01
影响因子：
2.2
通讯作者：
MIROUZE, J
中科院分区：
文献类型：
--
作者：
COLETTE, C;PARESHERBUTE, N;MIROUZE, J
IDDs的维生素D状况在3组患者中进行了研究，这些患者接受了几个月的治疗：（i）常规胰岛素治疗（I组，n= 17，HbA 1 = 10.1±0.5%）;（ii）持续皮下胰岛素输注（CSII，组II，n= 11，HbA 1 = 8.9±0.6%）;和（iii）连续腹膜内胰岛素输注（CPII，组HI，n= 13，HbA 1 = 8.0±0.4%）。在所有患者组中，维生素D代谢物的血浆浓度均在正常范围内。而血浆25 OHD（ng/ml）I组（13.0±0.8，P< 0.01）和II组（12.5±1.5，P< 0.02）明显低于III组（22.1±2.3，正常范围7-27）。血浆24，25-（OH）2 D（ng/ml）与血浆25 OH D（ng/ml）呈正相关，I组（1.5±0.2，P< 0.05）和II组（1.4±0.2，P< 0.05）显著低于III组（2.3±0.3，P< 0.05）。3组糖尿病患者血浆1，25-（OH）2D水平无显著性差异.三组血浆PTH相似。在CPII治疗的患者和与糖尿病对照组相匹配的15例皮下治疗患者（HbA 1小于10%）之间观察到血浆25 OH D的相同差异。本实验结果提示胰岛素对肝25羟化酶活性可能有刺激作用。
The vitamin D status of IDDs was studied in 3 groups of patients who were treated for several months with (i) conventional insulin therapy (group I, n= 17, HbA1= 10.1±0.5%);(ii) continuous subcutaneous insulin infusion (CSII, group II, n= 11, HbA1= 8.9±0.6%); and (iii) continuous intraperitoneal insulin infusion (CPII, group HI, n= 13, HbA1= 8.0±0.4%). In all patient groups the plasma concentration of vitamin D metabolites were within normal range. However plasma 25 OH D (ng/ml) was significantly lower in groups I (13.0±0.8, P< 0.01) and II (12.5±1.5, P< 0.02) than in group III: 22.1±2.3 (normal range 7-27). Plasma 24, 25-(OH) 2 D (ng/ml) was positively correlated to plasma 25 OH D and was significantly decreased in groups I (1.5±0.2, P< 0.05) and II (1.4±0.2, P< 0.05) compared with group III: 2.3±0.3. No significant differences were found in plasma 1, 25-(OH) 2 D between the three groups of diabetics. Plasma PTH was similar in the three groups. The same differences in plasma 25 OH D were observed between the patients treated with CPII and 15 subcutaneously treated patients matched for diabetic control (HbA1 less than 10 per cent). The present results seem to indicate that insulin might have a stimulatory effect on the hepatic 25 hydroxylase activity.