The effects of a whole grain-enriched hypocaloric diet on cardiovascular disease risk factors in men and women with metabolic syndrome
The effects of a whole grain-enriched hypocaloric diet on cardiovascular disease risk factors in men and women with metabolic syndrome
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DOI：
10.1093/ajcn/87.1.79
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发表时间：
2008-01-01
影响因子：
7.1
通讯作者：
Kris-Etherton, Penny M.
中科院分区：
文献类型：
--
作者：
Katcher, Heather I.;Legro, Richard S.;Kris-Etherton, Penny M.
Background: Whole-grain foods are associated in observational studies with a lower body mass index andlower body mass index and lower cardiovascular disease (CVD) risk. However, few clinical trials have tested whether incorporating whole grains into a hypocaloric diet increases weight loss and improves CVD risk factors.Objective: The aim of this study was to determine whether including whole-grain foods in a hypocaloric (reduced by 500 kcal/d) diet enhances weight loss and improves CVD risk factors.Design: Obese adults (25 M, 25 F) with metabolic syndrome were randomly assigned to receive dietary advice either to avoid whole-grain foods or to obtain all of their grain servings from whole grains for 12 wk. All participants were given the same dietary advice in other respects for weight loss.Results: Body weight, waist circumference, and percentage body fat decreased significantly (P < 0.001) in both groups over the study period, but there was a significantly (P = 0.03) greater decrease in percentage body fat in the abdominal region in the whole-grain group than in the refined-grain group. C-reactive protein (CRP) decreased 38% in the whole-grain group independent of weight loss but was unchanged in the refined-grain group (P = 0.01 for group X time interaction). Total, LDL, and HDL cholesterol decreased in both diet groups (P < 0.05). Dietary fiber and magnesium intakes increased in the whole-grain but not the refined-grain group (P = 0.007 and P < 0.001, respectively, for group x time interaction).Conclusions: Both hypocaloric diets were effective means of improving CVD risk factors with moderate weight loss. There were significantly (P < 0.05) greater decreases in CRP and percentage body fat in the abdominal region in participants consuming whole grains than in those consuming refined grains.
