Oncostatin M Is a Prognostic Biomarker and Inflammatory Mediator for Sepsis
Oncostatin M Is a Prognostic Biomarker and Inflammatory Mediator for Sepsis
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制瘤素 M 是脓毒症的预后生物标志物和炎症介质
DOI：
10.1093/infdis/jiaa009
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发表时间：
2020-06-15
影响因子：
6.4
通讯作者：
Cao, Ju
中科院分区：
文献类型：
--
作者：
Gong, Yi;Yan, Xingxing;Cao, Ju
背景抑瘤素M（Oncostatin M，OSM）是白细胞介素6家族的一种多效性细胞因子。OSM在脓毒症中的作用仍不清楚。在重症监护病房（ICU）入院当天测定并分析脓毒症患者的血清OSM水平。此外，还观察了OSM对盲肠结扎穿孔（CLP）诱导的多菌性脓毒症的治疗作用。在ICU入院当天，与ICU患者对照组和健康志愿者相比，脓毒症患者的血清OSM水平显著较高，这与脓毒症的严重程度相关，包括序贯（脓毒症相关）器官衰竭评估评分、降钙素原水平和白色血细胞数量等参数。ICU入院时高血清OSM水平与脓毒症患者28天死亡率相关。在CLP诱导的多微生物脓毒症中，抗OSM抗体减少了组织炎症和损伤，从而提高了存活率，而局部和全身细菌传播几乎是恒定的。补充重组OSM蛋白在脓毒症小鼠中增加了组织损伤，放大了炎症，并恶化了CI，P后的死亡率，而它并不影响脓毒症小鼠中的细菌传播。脓毒症导致OSM产生增加，这可能是脓毒症潜在的预后生物标志物和治疗靶点。
Background. Oncostatin M (OSM) is a pleiotropic cytokine of the interleukin-6 family. The role of OSM in sepsis remains unknown.Methods. Serum OSM level was determined and analyzed in septic patients on the day of intensive care unit (ICU) admission. Furthermore, the effects of OSM on polymicrobial sepsis induced by cecal ligation and puncture (CLP) were assessed.Results. On the day of ICU admission, septic patients had significantly higher serum OSM levels when compared with ICU patient controls and healthy volunteers, which were related to the severity of sepsis, including parameters such as the sequential (sepsis-related) organ failure assessment score, procalcitonin level, and white blood cell number. A high serum OSM level on ICU admission was associated with 28-day mortality in septic patients. In CLP-induced polymicrobial sepsis, anti-OSM antibody decreased tissue inflammation and injury, and thus improved survival, while local and systemic bacterial dissemination was almost constant. Complementarily, supplementation with recombinant OSM protein in septic mice increased tissue injury, amplified inflammation, and worsened mortality after CI,P, while it did not affect bacterial dissemination in septic mice.Conclusions. Sepsis results in an increased production of OSM, which might be a potential prognostic biomarker and therapeutic target for sepsis.