Higher daily physical activity is associated with higher osteocalcin levels in adolescents.
Higher daily physical activity is associated with higher osteocalcin levels in adolescents.
复制标题
青少年较高的日常体力活动与较高的骨钙素水平相关。
DOI：
10.1016/j.pmedr.2015.06.017
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发表时间：
2015
影响因子：
2.8
通讯作者：
Polgreen,LyndaE
中科院分区：
文献类型：
--
作者：
Chahla,SaydiE;Frohnert,BrigitteI;Thomas,William;Kelly,AaronS;Nathan,BrandonM;Polgreen,LyndaE
背景运动刺激骨重建和改善胰岛素敏感性（Si），即使没有相关的体重减轻。骨钙素（OCN），骨源性蛋白质，与改善Si.PurposeWe研究如何日常体力活动与OCN和Si.MethodsPhysical活动是通过在明尼阿波利斯完成的问卷调查，从2010年至2012年进行测量。计算身体活动评分（PAQsum）以量化身体活动（范围1-5）。ELISA法测定骨钙素（OCN）和骨特异性碱性磷酸酶（BAP）。结果47名受试者（12 ~ 17.9岁）的PAQsum平均值为2.4 ± 0.8。PAQsum与OCN呈正相关（p = 0.006）。PAQsum 2的参与者< 2 had significantly lower OCN levels compared to participants with PAQsum >（p < 0.02）。肥胖并没有改变PAQsum和OCN之间的关联。有PAQsum和硅或OCN和硅之间没有统计学意义上的关联，即使调整后的体脂百分比。需要更多的研究来阐明OCN，体力活动和Si之间的关系。
BackgroundExercise stimulates bone remodeling and improves insulin sensitivity (Si), even without associated weight loss. Osteocalcin (OCN), a bone-derived protein, is associated with improved Si.PurposeWe examined how daily physical activity is associated with OCN and Si.MethodsPhysical activity was measured through questionnaires completed in Minneapolis from 2010 to 2012. A physical activity score (PAQsum) was calculated to quantify physical activity (range 1–5). OCN and bone specific alkaline phosphatase (BAP) were measured by ELISA. Si was measured by the insulin modified frequently sampled IV glucose tolerance test.ResultsThe mean PAQsum value was 2.4 ± 0.8 in 47 participants (12–17.9 years old). PAQsum was positively associated with OCN (p = 0.006). Participants with PAQsum < 2 had significantly lower OCN levels compared to participants with PAQsum > 2 (p < 0.02). Obesity did not modify the association between PAQsum and OCN. There was no statistically significant association between PAQsum and Si or between OCN and Si, even after adjustment for percent body fat.ConclusionsOCN is higher in more physically active individuals. More research is needed to clarify the relationship between OCN, physical activity and Si.