DOTting the path to doom: how acceleration of histone methylation leads to leukemia.
DOTting the path to doom: how acceleration of histone methylation leads to leukemia.
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DOI：
10.1016/j.ccell.2014.11.004
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发表时间：
2014-12
期刊：
影响因子：
50.3
通讯作者：
C. Bach;R. Slany
中科院分区：
文献类型：
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作者：
C. Bach;R. Slany
表观遗传控制机制是正常和恶性造血的核心。在这一期的《癌细胞》杂志上，Deshpande和他的同事证明，AF10是组蛋白甲基转移酶DOT1L的相互作用伙伴，对H3K79的有效甲基化至关重要，从而调节髓性白血病中hox基因的转录和转化。
Epigenetic control mechanisms are central to normal and malignant hematopoiesis. In this issue ofCancer Cell, Deshpande and colleagues demonstrate that AF10, an interaction partner of the histone methyltransferase DOT1L, is essential for efficient H3K79 methylation, thus regulatingHOX-gene transcription and transformation in myeloid leukemia.