Genetic and functional analysis of beta tubulin in Aspergillus nidulans.
Genetic and functional analysis of beta tubulin in Aspergillus nidulans.
复制标题
构巢曲霉β微管蛋白的遗传和功能分析。
DOI：
10.1111/j.1749-6632.1986.tb38380.x
复制
发表时间：
1986
影响因子：
5.2
通讯作者：
Gambino,J
中科院分区：
文献类型：
--
作者：
Morris,NR;May,GS;Weatherbee,JA;Tsang,ML;Gambino,J
在曲霉菌中，与大多数其他真核生物一样，存在由相关基因家族编码的许多微管蛋白多肽。两种α-微管蛋白多肽α 1和α 3由tub A基因编码，第三种α-微管蛋白α 2由另一种基因tub B编码。类似地，两种β-微管蛋白多肽β 1和β 2由ben A基因编码，第三种多肽β 3由tub C编码。在ben A和tub A基因中已经鉴定出许多突变，这些突变有助于分析ben A和tub A基因产物的功能;但是，迄今为止，还没有在tub B或tub C基因中描述过突变。
In Aspergillus, as in most other eukaryotes, there are a number of tubulin polypeptides that are coded by a family of related genes. Two alpha-tubulin polypeptides, alpha 1 and alpha 3, are coded by the tub A gene and a third alpha tubulin, alpha 2, by another gene, tub B.'Similarly, two beta-tubulin polypeptides, beta 1 and beta 2, are coded by the ben A gene, and a third polypeptide, beta 3, is coded by tub C.'A number of mutations have been identified in the ben A and tub A genes that have been helpful in analyzing the functions of the ben A and tub A gene products; but, heretofore, no mutations have been described in the tub B or tub C genes.